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H2S, a Bacterial Defense Mechanism against the Host Immune Response

Toliver-Kinsky, Tracy ; Cui, Weihua ; Törö, Gabor ; Lee, Seung-Jin ; Shatalin, Konstantin ; Nudler, Evgeny ; Szabo, Csaba

In: Infection and Immunity, 2019, vol. 87, no. 1, p. e00272-18

The biological mediator hydrogen sulfide (H2S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H2S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections,...