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How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

Rehrauer, Hubert ; Wu, Licun ; Blum, Walter ; Pecze, Lazslo ; Henzi, Thomas ; Serre-Beinier, Véronique ; Aquino, Catherine ; Vrugt, Bart ; Perrot, Marc de ; Schwaller, Beat ; Felley-Bosco, Emanuela

In: Oncogene, 2018, vol. 37, no. 20, p. 2645–2659

Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with...

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

Serre-Beinier, Véronique ; Bosco, Domenico ; Zulianello, Laurence ; Charollais, Anne ; Caille, Dorothée ; Charpantier, Eric ; Gauthier, Benoit R. ; Diaferia, Giuseppe R. ; Giepmans, Ben N. ; Lupi, Roberto ; Marchetti, Piero ; Deng, Shaoping ; Buhler, Léo ; Berney, Thierry ; Cirulli, Vincenzo ; Meda, Paolo

In: Human Molecular Genetics, 2009, vol. 18, no. 3, p. 428-439