In: Frontiers in Human Neuroscience, 2019, vol. 13, p. -
The role of the sensorimotor system in second language (L2) semantic processing as well as its clinical implications for bilingual patients has hitherto been neglected. We offer an overview of the issues at stake in this under-investigated field, presenting the theoretical and clinical relevance of studying L2 embodiment and reviewing the few studies on this topic. We highlight that (a) the...
|
In: Clinical Microbiology Reviews, 2019, vol. 32, no. 2, p. e00084-18
There is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight,...
|
In: Biochemical Pharmacology, 2019, vol. 162, p. 98–108
The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 inhibition activates Akt, and showed that this response plays a critical role in the maintenance of mitochondrial integrity and in cell survival. However, it has not yet been defined how nuclear PARP1...
|
In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833
The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...
|
In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44
The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...
|
In: Frontiers in Cellular Neuroscience, 2019, vol. 13, p. -
Chromatin immunoprecipitation (ChIP) is an assay developed in order to define the dynamic nature of transcription processes. This method has been widely employed to identify methylated and acetylated DNA sequences in a variety of organs both in animals and humans. Nevertheless, this technique is significantly less employed to study transcriptional targets of specific nuclear signaling factors...
|
In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478
Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...
|
In: Pacific Journal of Mathematics, 2019, vol. 298, no. 2, p. 267–284
|
In: Annali di Matematica Pura ed Applicata (1923 -), 2019, vol. 198, no. 2, p. 367–380
We prove local Hölder continuity of quasi-n-harmonic mappings from Euclidean domains into metric spaces with non-positive curvature in the sense of Alexandrov. We also obtain global Hölder continuity of such mappings from bounded Lipschitz domains.
|
In: Calculus of Variations and Partial Differential Equations, 2019, vol. 58, no. 2, p. 69
We show that a complete doubling metric space (X,d,μ) supports a weak 1-Poincaré inequality if and only if it admits a pencil of curves (PC) joining any pair of points s,t∈X . This notion was introduced by S. Semmes in the 90’s, and has been previously known to be a sufficient condition for the weak 1-Poincaré inequality. Our argument passes through the intermediate notion of a...
|