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FLC or not FLC: the other side of vernalization

Alexandre, Cristina Madeira ; Hennig, Lars

In: Journal of Experimental Botany, 2008, vol. 59, no. 6, p. 1127-1135

Université de Neuchâtel

Nucleotide binding and dimerization at the chloroplast pre-protein import receptor, atToc33, are not essential in vivo but do increase import efficiency

Aronsson, Henrik ; Combe, Jonathan ; Patel, Ramesh ; Agne, Birgit ; Martin, Meryll ; Kessler, Felix ; Jarvis, Paul

In: The Plant Journal, 2010, vol. 63, no. 2, p. 297-311

The atToc33 protein is one of several pre-protein import receptors in the outer envelope of Arabidopsis chloroplasts. It is a GTPase with motifs characteristic of such proteins, and its loss in the plastid protein import 1 (ppi1) mutant interferes with the import of photosynthesis-related pre-proteins, causing a chlorotic phenotype in mutant plants. To assess the significance of GTPase...

Université de Fribourg

Systemic resistance in citrus to Tetranychus urticae induced by conspecifics is transmitted by grafting and mediated by mobile amino acids

Agut, Blas ; Gamir, Jordi ; Jaques, Josep A. ; Flors, Victor

In: Journal of Experimental Botany, 2016, vol. 67, no. 19, p. 5711–5723

Recent research suggests that systemic signalling and communication between roots and leaves plays an important role in plant defence against herbivores. In the present study, we show that the oviposition of the two-spotted spider mite Tetranychus urticae in the systemic leaves of citrus rootstock Citrus aurantium (sour orange) was reduced by 50% when a lower leaf was previously infested with...

Université de Fribourg

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling

Asparuhova, Maria B. ; Secondini, Chiara ; Rüegg, Curzio ; Chiquet-Ehrismann, Ruth

In: Molecular Oncology, 2015, vol. 9, no. 8, p. 1510–1527

Radiotherapy is a standard treatment after conservative breast cancer surgery. However, cancers relapsing within a previously irradiated area have an increased probability to metastasize. The mechanisms responsible for this aggressiveness remain unclear. Here, we used the clinically relevant 4T1 breast cancer model mimicking aggressive local relapse after radiotherapy to identify differences...

Université de Fribourg

CD103 is a hallmark of tumor-infiltrating regulatory T cells

Anz, David ; Mueller, Wolfgang ; Golic, Michaela ; Kunz, Wolfgang G. ; Rapp, Moritz ; Koelzer, Viktor H. ; Ellermeier, Jonathan ; Ellwart, Joachim W. ; Schnurr, Max ; Bourquin, Carole ; Endres, Stefan

In: International Journal of Cancer, 2012, vol. 129, no. 10, p. 2417–2426

Regulatory T cells (Treg) mediate tolerance towards self-antigens by suppression of innate and adaptive immunity. In cancer patients, tumor-infiltrating FoxP3+ Treg suppress local anti-tumor immune responses and are often associated with poor prognosis. Markers that are selectively expressed on tumor-infiltrating Treg may serve as targets for immunotherapy of cancer. Here we show that CD103, an...

Université de Fribourg

Pseudomonas syringae Elicits Emission of the Terpenoid (E,E)-4,8,12-Trimethyl-1,3,7,11-Tridecatetraene in Arabidopsis Leaves Via Jasmonate Signaling and Expression of the Terpene Synthase TPS4

Attaran, Elham ; Rostás, Michael ; Zeier, Jürgen

In: Molecular Plant-Microbe Interactions, 2008, vol. 21, no. 11, p. 1482-1497

Volatile, low–molecular weight terpenoids have been implicated in plant defenses, but their direct role in resistance against microbial pathogens is not clearly defined. We have examined a possible role of terpenoid metabolism in the induced defense of Arabidopsis thaliana plants against leaf infection with the bacterial pathogen Pseudomonas syringae. Inoculation of plants with...

Université de Fribourg

Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light

Abraham, Diya ; Dallmann, Robert ; Steinlechner, Stephan ; Albrecht, Urs ; Eichele, Gregor ; Oster, Henrik

In: Journal of Biological Rhythms, 2006, vol. 21(3), p. 169-176

In mammals, circadian rhythms in behavior and physiology are controlled by a central pacemaker, the SCN, and subordinated clocks throughout the body. On the molecular level, these clocks are based on transcriptional/translational feedback loops involving a set of clock genes that regulate their own transcription. Among the components driving the mammalian circadian clock are the Period 1...