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Université de Fribourg

PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

Tapodi, Antal ; Bognar, Zita ; Szabo, Csaba ; Gallyas, Ferenc ; Sumegi, Balázs ; Hocsak, Enikő

In: Biochemical Pharmacology, 2019, vol. 162, p. 98–108

The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 inhibition activates Akt, and showed that this response plays a critical role in the maintenance of mitochondrial integrity and in cell survival. However, it has not yet been defined how nuclear PARP1...

Université de Fribourg

Extending the mathematical palette for developmental pattern formation: piebaldism

Dougoud, Michaël ; Mazza, Christian ; Schwaller, Beat ; Pecze, László

In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478

Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...

Université de Fribourg

Pleistocene sea-floor fibrous crusts and spherulites in the Danakil Depression (Afar, Ethiopia)

Jaramillo‐Vogel, David ; Foubert, Anneleen ; Braga, Juan Carlos ; Schaegis, Jean‐Charles ; Atnafu, Balemwal ; Grobéty, Bernard ; Kidane, Tesfaye

In: Sedimentology, 2019, vol. 66, no. 2, p. 480–512

Pleistocene fibrous aragonite fabrics, including crusts and spherules, occur in the Danakil Depression (Afar, Ethiopia) following the deposition of two distinctive Middle and Late Pleistocene coralgal reef units and pre‐dating the precipitation of evaporites. Crusts on top of the oldest reef unit (Marine Isotope Stage 7) cover and fill cavities within a red algal framework. The younger...

Université de Fribourg

Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

Maurya, Anjani K. ; Weidenbacher, Lukas ; Spano, Fabrizio ; Fortunato, Giuseppino ; Rossi, René M. ; Frenz, Martin ; Dommann, Alex ; Neels, Antonia ; Sadeghpour, Amin

In: Nanoscale, 2019, vol. 11, no. 15, p. 7176–7187

A dedicated nanofiber design for applications in the biomedical domain is based on the understanding of nanofiber structures. The structure of electrospun nanofibers strongly influences their properties and functionalities. In polymeric nanofibers X-ray scattering and diffraction methods, i.e. SAXS and WAXD, are capable of decoding their structural insights from about 100 nm down to the...

Università della Svizzera italiana

Polarization of migrating monocytic cells is independent of PI 3-Kinase activity

Volpe, Silvia ; Thelen, Sylvia ; Pertel. Thomas ; Lohse, Martin J. ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 4, p. e10159

Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...

Université de Fribourg

Tautomerism in azo dyes: Border cases of azo and hydrazo tautomers as possible NMR reference compounds

Deneva, Vera ; Lyčka, Antonin ; Hristova, S. ; Crochet, Aurélien ; Fromm, Katharina M. ; Antonov, Liudmil M.

In: Dyes and Pigments, 2019, vol. 165, p. 157–163

In order to meet the need for NMR reference compounds in the study of tautomeric azo dyes, two series of azo dyes, derived from 3-methyl-1-phenyl-4- (phenyldiazenyl)-1H-pyrazol-5-amine and 5-methyl-2-phenyl-4-(2- phenylhydrazono)-2,4-dihydro-3H-pyrazol-3-one, have been studied by using molecular spectroscopy (UV–Vis and NMR) and quantum-chemical calculations (M06- 2X/TZVP) in solution. The...

Université de Fribourg

Prospect for supramolecular chemistry in high-energy-density rechargeable batteries

Kwon, Tae-woo ; Choi, Jang Wook ; Coskun, Ali

In: Joule, 2019, vol. 3, no. 3, p. 662–682

The quest for new electrode materials for Li-ion batteries with high energy densities beyond conventional intercalation-based electrodes has gained significant attention due to the increasing demand for advanced portable devices and electric vehicles (EVs). Among various candidates, the most promising electrode materials along this direction are silicon and Li metal for anodes and sulfur for...

Université de Fribourg

Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert ; Ngono Bikobo, Dominique Serge ; Zintchem, Auguste Abouem A. ; Mbabi Nyemeck II, Norbert ; Moni Ndedi, Esther Del Florence ; Betote Diboué, Patrick Hervé ; Nyegue, Maximilienne Ascension ; Atchadé, Alex de Théodore ; Pegnyemb, Dieudonné Emmanuel ; Bochet, Christian G. ; Koert, Ulrich

In: Natural Product Research, 2019, vol. 33, no. 5, p. 642–650

Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol...

Université de Neuchâtel

Semantic content in titi monkey alarm call sequences

Berthet, Mélissa ; Zuberbühler, Klaus (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

L'approche comparative cherche à comprendre ce qui rend le langage humain si unique et comment il a évolué. Les singes titi à front noir Callicebus nigrifrons possèdent deux cris d’alarme de courte portée : les cris A, spécifiques aux menaces de la canopée, et les cris B, des cris généraux émis en présence d’un prédateur terrestre ou lorsque les singes descendent près du...

Université de Fribourg

Templated assembly of pore-forming peptides in lipid membranes

Fennouri, Aziz ; List, Jonathan ; Dupasquier, Jessica ; Haeni, Laetitia ; Vanni, Stefano ; Rothen-Rutishauser, Barbara ; Mayer, Michael

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 59–62

Pore-forming peptides are of interest due to their antimicrobial activity and ability to form gateways through lipid membranes. Chemical modification of these peptides makes it possible to arrange several peptide monomers into well-defined pore-forming structures using various templating strategies. These templated super-structures can exert antimicrobial activity at significantly lower total...