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Università della Svizzera italiana

Deciphering the complexity of human noncoding promoter-proximal transcriptome : different scales of transcriptional control : from a single gene to the whole epigenome

Mapelli, Sarah Natalia ; Krause, Rolf (Dir.) ; Catapano, Carlo V. (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO001.

Long noncoding RNAs (lncRNAs) have gained increasing interest in molecular studies, their active participation in important biological functions has emerged and their direct involvement in genomic reprogramming during development and diseases, including cancer, has been demonstrated. Several studies have shown their active contribution in transcriptional control and they are emerging as...

Université de Neuchâtel

Erasure coding for distributed storage systems

Barbi, Roberta ; Mercier, Hughes (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Une énorme quantité de données est désormais générée et stockée : 300 millions de photos sont téléchargées sur Facebook chaque jour et 156 millions de courriels sont envoyés chaque minute. Par ailleurs, près de 90% des données dans le monde ont été produites au cours de deux dernières années. Cette quantité colossale de données est typiquement hébergée dans des centres de...

Università della Svizzera italiana

Consensus protocols exploiting network programmability

Dang, Huynh Tu ; Soulé, Robert (Dir.) ; Pedone, Fernando (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO003.

Services rely on replication mechanisms to be available at all time. The service demanding high availability is replicated on a set of machines called replicas. To maintain the consistency of replicas, a consensus protocol such as Paxos or Raft is used to synchronize the replicas' state. As a result, failures of a minority of replicas will not affect the service as other non-faulty replicas...

Università della Svizzera italiana

High performance selected inversion methods for sparse matrices : direct and stochastic approaches to selected inversion

Verbosio, Fabio ; Schenk, Olaf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO002.

The explicit evaluation of selected entries of the inverse of a given sparse matrix is an important process in various application fields and is gaining visibility in recent years. While a standard inversion process would require the computation of the whole inverse who is, in general, a dense matrix, state-of-the-art solvers perform a selected inversion process instead. Such approach allows...

Université de Neuchâtel

On reducing latency in geo-distributed systems through state partitioning and caching

Halalai, Raluca ; Felber, Pascal (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes distribués modernes sont de plus en plus grands, et sont déployés dans plusieurs régions géographiques. L’objectif final de tels systèmes est de fournir des services à leurs utilisateurs ainsi que haute disponibilité et bonne performance. Cette thèse propose des techniques pour réduire le latence perçue par des utilisateurs. Pour commencer, nous...

Accès public à partir du 15 janv. 2021
Università della Svizzera italiana

Modelling protein-protein interactions to elucidate molecular mechanisms behind neurodegenerative diseases

Grasso, Gianvito ; Krause, Rolf (Dir.) ; Danani, Andrea (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.

The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...

Università della Svizzera italiana

Exposing concurrency failures : a comprehensive survey of the state of the art and a novel approach to reproduce field failures

Bianchi, Francesco Adalberto ; Pezzè, Mauro (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO015.

With the rapid advance of multi-core and distributed architectures, concurrent systems are becoming more and more popular. Concurrent systems are extremely hard to develop and validate, as their overall behavior depends on the non-deterministic interleaving of the execution flows that comprise the system. Wrong and unexpected interleavings may lead to concurrency faults that are extremely...

Università della Svizzera italiana

Tracking public opinion on social media

Giachanou, Anastasia ; Crestani, Fabio (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO016.

The increasing popularity of social media has changed the web from a static repository of information into a dynamic forum with continuously changing information. Social media platforms has given the capability to people expressing and sharing their thoughts and opinions on the web in a very simple way. The so-called User Generated Content is a good source of users opinion and mining it can be...

Università della Svizzera italiana

Reification as the key to augmenting software development : an object is worth a thousand words

Dal Sasso, Tommaso ; Lanza, Michele (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO014.

Software development has become more and more pervasive, with influence in almost every human activity. To be able to fit in so many different scenarios and constantly implement new features, software developers adopted methodologies with tight development cycles, sometimes with more than one release per day. With the constant growth of modern software projects and the consequent expansion...

Université de Neuchâtel

Multimodal information retrieval

Geiger, Melanie ; Savoy, Jacques (Dir.) ; Braschler, Martin (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les processus basés sur le savoir, une des composantes essentielles de notre économie, requiert souvent un système multimodal de recherche d’information. De tels systèmes doivent traiter des collections de documents et des requêtes de plus en plus complexes. Cette complexité sous-jacente se situe dans le grand nombre et la diversité des modalités textuelles ou non-textuelles comme les...