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Université de Fribourg

CX 3 CR1-CX 3 CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells

Lannes, Nils ; Garcia-Nicolàs, Obdullio ; Démoulins, Thomas ; Summerfield, Artur ; Filgueira, Luis

In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833

The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...

Université de Fribourg

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Petrini, Francesco M. ; Mazzoni, Alberto ; Rigosa, Jacopo ; Giambattistelli, Federica ; Granata, Giuseppe ; Barra, Beatrice ; Pampaloni, Alessandra ; Guglielmelli, Eugenio ; Zollo, Loredana ; Capogrosso, Marco ; Micera, Silvestro ; Raspopovic, Stanisa

In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44

The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...

Université de Fribourg

TF-ChIP Method for Tissue-Specific Gene Targets

Perna, Amalia ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2019, vol. 13, p. -

Chromatin immunoprecipitation (ChIP) is an assay developed in order to define the dynamic nature of transcription processes. This method has been widely employed to identify methylated and acetylated DNA sequences in a variety of organs both in animals and humans. Nevertheless, this technique is significantly less employed to study transcriptional targets of specific nuclear signaling factors...

Université de Fribourg

Extending the mathematical palette for developmental pattern formation: piebaldism

Dougoud, Michaël ; Mazza, Christian ; Schwaller, Beat ; Pecze, László

In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478

Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...

Université de Fribourg

Expected depth of random walks on groups

Bou-Rabee, Khalid ; Manolescu, Ioan ; Myropolska, Aglaia

In: Pacific Journal of Mathematics, 2019, vol. 298, no. 2, p. 267–284

Université de Fribourg

Regularity of quasi-n-harmonic mappings into NPC spaces

Guo, Chang-Yu ; Xiang, Chang-Lin

In: Annali di Matematica Pura ed Applicata (1923 -), 2019, vol. 198, no. 2, p. 367–380

We prove local Hölder continuity of quasi-n-harmonic mappings from Euclidean domains into metric spaces with non-positive curvature in the sense of Alexandrov. We also obtain global Hölder continuity of such mappings from bounded Lipschitz domains.

Université de Fribourg

Metric currents and the Poincaré inequality

Fässler, Katrin ; Orponen, Tuomas

In: Calculus of Variations and Partial Differential Equations, 2019, vol. 58, no. 2, p. 69

We show that a complete doubling metric space (X,d,μ) supports a weak 1-Poincaré inequality if and only if it admits a pencil of curves (PC) joining any pair of points s,t∈X . This notion was introduced by S. Semmes in the 90’s, and has been previously known to be a sufficient condition for the weak 1-Poincaré inequality. Our argument passes through the intermediate notion of a...

Université de Fribourg

Convexity of complements of tropical varieties, and approximations of currents

Adiprasito, Karim ; Babaee, Farhad

In: Mathematische Annalen, 2019, vol. 373, no. 1, p. 237–251

The goal of this note is to affirm a local version of conjecture of Nisse–Sottile [19] on higher convexity of complements of tropical varieties, while providing a family of counter-examples for the global Nisse–Sottle conjecture in any codimension and dimension higher than one. Moreover, it is shown that, surprisingly, this family also provides a family of counter-examples for the...

Université de Fribourg

Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic centre

Jermini, Mégane ; Dubois, Julie ; Rodondi, Pierre-Yves ; Zaman, Khalil ; Buclin, Thierry ; Csajka, Chantal ; Orcurto, Angela ; Rothuizen, Laura E .

In: Scientific Reports, 2019, vol. 9, no. 1, p. 5078

Complementary medicine (CM) is used by one third to one half of cancer patients throughout the world. The objective of this study was to describe the prevalence of CM use and the potential for interactions with cancer treatments in an academic oncology centre. A cross-sectional study was conducted among patients undergoing current cancer treatment. Among 132 included patients, 56% had used CM...

Université de Fribourg

Climate change research in bilateral development programmes: experiences from India and Peru

Muccione, Veruska ; Orlowsky, Boris ; Allen, Simon K. ; Huggel, Christian ; Salzmann, Nadine ; Montoya, Nilton ; Randhawa, Surjeet Singh ; Stoffel, Markus

In: Development in Practice, 2019, vol. 29, no. 3, p. 336–348

This article reflects on the merits and shortfalls of bilateral research programmes aimed at strengthening climate change research capabilities, using the experience from two programmes, the PACC and IHCAP in Peru and India, respectively. The study highlights key aspects of these types of bilateral programmes, namely: capacity; performance, salary and appreciation; funding; bureaucracy and...