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Université de Fribourg

Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys

Beaud, Marie-Laure ; Rouiller, Eric M. ; Bloch, Jocelyne ; Mir, Anis ; Schwab, M.E. ; Wannier, Thierry ; Schmidlin, Eric

In: Neuroscience, 2012, vol. 27, p. 271–282

In adult macaque monkeys subjected to an incomplete spinal cord injury (SCI), corticospinal (CS) fibers are rarely observed to grow in the lesion territory. This situation is little affected by the application of an anti-Nogo-A antibody which otherwise fosters the growth of CS fibers rostrally and caudally to the lesion. However, when using the Sternberger monoclonal-incorporated antibody 32...

Université de Fribourg

A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Schmidlin, Eric ; Jouffrais, Christophe ; Freund, Patrick ; Wannier-Morino, Patrizia ; Beaud, Marie-Laure ; Rouiller, Eric M. ; Wannier, Thierry

In: BMC Neuroscience, 2009, vol. 10, p. 155

Background Polymicrogyria is a malformation of the cerebral cortex often resulting in epilepsy or mental retardation. It remains unclear whether this pathology affects the structure and function of the corticospinal (CS) system. The anatomy and histology of the brain of one macaque monkey exhibiting a spontaneous polymicrogyria (PMG monkey) were examined and compared to the brain of normal...

Université de Fribourg

Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

Beaud, Marie-Laure ; Schmidlin, Eric ; Wannier, Thierry ; Freund, Patrick ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E. ; Rouiller, Eric M.

Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS neurons...