In: European Heart Journal, 2013, vol. 34, no. 34, p. 2674-2682
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In: European Journal of Cardio-Thoracic Surgery, 2004, vol. 25, no. 4, p. 635-641
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In: European Journal of Cardio-Thoracic Surgery, 2004, vol. 26, no. 1, p. 60-65
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In: Cardiovascular Therapeutics, 2017, vol. 35, no. 2, p. -
Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction...
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In: European Heart Journal, 2016, vol. 37, no. 26, p. 2040–2049
Background Peri-stent coronary evaginations may disturb flow and have been proposed as possible risk factor for late stent thrombosis. We describe incidence, predictors, and possible mechanisms of coronary evaginations 12 months after implantation of bioresorbable vascular scaffolds (BVS).Methods and results One hundred and two BVS implanted in 90 patients...
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In: SPIE Proceedings, 2015, vol. 9542, p. 95420Z–95420Z–6
Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and increasingly susceptible to rupturing and causing a potentially lethal thrombosis. The stabilization and/or treatment of atherosclerotic...
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In: Cardiovascular Research, 2013, vol. 99, no. 2, p. 328-333
Stenosed segments of arteries significantly alter the blood flow known from healthy vessels. In particular, the wall shear stress at critically stenosed arteries is at least an order of magnitude higher than in healthy situations. This alteration represents a change in physical force and might be used as a trigger signal for drug delivery. Mechanosensitive drug delivery systems, that...
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In: PLoS ONE, 2012, vol. 7, no. 8, p. e43642
Aims: Cardiac grafts from non-heartbeating donors (NHBDs) could significantly increase organ availability and reduce waiting-list mortality. Reluctance to exploit hearts from NHBDs arises from obligatory delays in procurement leading to periods of warm ischemia and possible subsequent contractile dysfunction. Means for early prediction of graft suitability prior to transplantation are thus...
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In: Development, 2010, vol. 137, p. 2187-2196
In the developing chicken embryo yolk sac vasculature, the expression of arterial identity genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must provide a unique signal that is relevant for supporting arterial identity gene expression and is absent in veins. We analyzed factors related to flow, pressure and oxygenation in the chicken embryo vitelline...
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In: Optics Express, 2009, vol. 17, no. 16, p. 13904-13917
Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed...
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