In: Rheumatology, 2010, vol. 49, p. i26-i28
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In: Rheumatology, 2007, vol. 46, no. 12, p. 1779-1785
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In: Nephrology Dialysis Transplantation, 2004, vol. 19, no. 7, p. 1875-1880
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In: European Heart Journal, 2014, vol. 35, no. 43, p. 3013-3020
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In: Cardiovascular Research, 2008, vol. 78, no. 1, p. 158-166
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In: European Heart Journal, 2010, vol. 31, no. 18, p. 2301-2309
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In: Cardiovascular Therapeutics, 2017, vol. 35, no. 2, p. -
Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction...
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In: SPIE Proceedings, 2015, vol. 9542, p. 95420Z–95420Z–6
Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and increasingly susceptible to rupturing and causing a potentially lethal thrombosis. The stabilization and/or treatment of atherosclerotic...
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In: Biomedical Optics Express, 2015, vol. 6, no. 7, p. 2552
We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on...
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In: Journal of the American Heart Association, 2013, vol. 2, no. 4, p. e000096
Background Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and activation of macrophage inflammation. The function of Arg‐II in VSMCs with respect to plaque...
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