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Université de Fribourg

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Jain, Manish ; Zellweger, Matthieu ; Wagnières, Georges ; Bergh, Hubert van den ; Cook, Stéphane ; Giraud, Marie-Noëlle

In: Cardiovascular Therapeutics, 2017, vol. 35, no. 2, p. -

Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction...

Université de Fribourg

Ultrafast laser ablation for targeted atherosclerotic plaque removal

Lanvin, Thomas ; Conkey, Donald B. ; Descloux, Laurent ; Frobert, Aurelien ; Valentin, Jeremy ; Goy, Jean-Jacques ; Cook, Stéphane ; Giraud, Marie-Noelle ; Psaltis, Demetri

In: SPIE Proceedings, 2015, vol. 9542, p. 95420Z–95420Z–6

Coronary artery disease, the main cause of heart disease, develops as immune cells and lipids accumulate into plaques within the coronary arterial wall. As a plaque grows, the tissue layer (fibrous cap) separating it from the blood flow becomes thinner and increasingly susceptible to rupturing and causing a potentially lethal thrombosis. The stabilization and/or treatment of atherosclerotic...

Université de Fribourg

Subsurface ablation of atherosclerotic plaque using ultrafast laser pulses

Lanvin, Thomas ; Conkey, Donald B. ; Frobert, Aurelien ; Valentin, Jeremy ; Goy, Jean-Jacques ; Cook, Stéphane ; Giraud, Marie-Noelle ; Psaltis, Demetri

In: Biomedical Optics Express, 2015, vol. 6, no. 7, p. 2552

We perform subsurface ablation of atherosclerotic plaque using ultrafast pulses. Excised mouse aortas containing atherosclerotic plaque were ablated with ultrafast near-infrared (NIR) laser pulses. Optical coherence tomography (OCT) was used to observe the ablation result, while the physical damage was inspected in histological sections. We characterize the effects of incident pulse energy on...

Université de Fribourg

Arginase‐II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l‐arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability

Xiong, Yuyan ; Yu, Yi ; Montani, Jean‐Pierre ; Yang, Zhihong ; Ming, Xiu‐Fen

In: Journal of the American Heart Association, 2013, vol. 2, no. 4, p. e000096

Background Vascular smooth muscle cell (VSMC) senescence and apoptosis are involved in atherosclerotic plaque vulnerability. Arginase‐II (Arg‐II) has been shown to promote vascular dysfunction and plaque vulnerability phenotypes in mice through uncoupling of endothelial nitric oxide synthase and activation of macrophage inflammation. The function of Arg‐II in VSMCs with respect to plaque...