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Secular Trend and Risk Factors for Antimicrobial Resistance in Escherichia coli Isolates in Switzerland 1997-2007

Blaettler, L. ; Mertz, D. ; Frei, R. ; Elzi, L. ; Widmer, A. ; Battegay, M. ; Flückiger, U.

In: Infection, 2009, vol. 37, no. 6, p. 534-539

Functional expression of arginine kinase improves recovery from pH stress of Escherichia coli

Canonaco, Fabrizio ; Schlattner, Uwe ; Wallimann, Theo ; Sauer, Uwe

In: Biotechnology Letters, 2003, vol. 25, no. 13, p. 1013-1017

Complete genome sequencing of Acinetobacter baumannii str. K50 disclosed the large conjugative plasmid pK50a encoding the carbapenemase OXA-23 and the extended-spectrum β–lactamase GES-11

Wibberg, Daniel ; Salto, Ileana P. ; Eikmeyer, Felix G. ; Maus, Irena ; Winkler, Anika ; Nordmann, Patrice ; Pühler, Alfred ; Poirel, Laurent ; Schlüter, Andreas

In: Antimicrobial Agents and Chemotherapy, 2018, p. AAC.00212-18

Multidrug-resistant (MDR) Acinetobacter baumannii strains appeared as serious emerging nosocomial pathogens in clinical environments and especially in intensive care units (ICUs). A. baumannii strain K50 recovered from a hospitalized patient in Kuwait exhibited resistance to carbapenems, and additionally to ciprofloxacin, chloramphenicol, sulfonamides, amikacin and gentamicin. Genome...

High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal

Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent

In: Emerging Infectious Diseases, 2017, vol. 23, no. 12, p. 2023–2029

The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing...

Key features of mcr-1-bearing plasmids from Escherichia coli isolated from humans and food

Zurfluh, Katrin ; Nüesch-Inderbinen, Magdalena ; Klumpp, Jochen ; Poirel, Laurent ; Nordmann, Patrice ; Stephan, Roger

In: Antimicrobial Resistance & Infection Control, 2017, vol. 6, p. 91

Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins.

Co-production of MCR-1 and extended-spectrum β-lactamase in Escherichia coli recovered from urinary tract infections in Switzerland

Kieffer, Nicolas ; Poirel, Laurent ; Clerc, Olivier ; Lienhard, Reto ; Nordmann, Patrice

In: Infection, 2017, p. 1–2

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

Alvarez-Marin, R. ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Kieffer, Nicolas ; Poirel, Laurent

In: European Journal of Clinical Microbiology & Infectious Diseases, 2017, p. 1–5

Multidrug-resistant (MR) Gram-negative (GN) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. Well-tolerated antiseptics, such as octenidine dihydrochloride (OCT), may be a very useful tool in infection control to reduce the dissemination of MRGN. This study aimed to investigate the...

Increased colistin resistance upon acquisition of the plasmid-mediated mcr-1 gene in Escherichia coli isolates with chromosomally encoded reduced susceptibility to polymyxins

Jayol, Aurélie ; Nordmann, Patrice ; André, Catherine ; Dubois, Véronique ; Poirel, Laurent

In: International Journal of Antimicrobial Agents, 2017, vol. 50, no. 3, p. 503–504

Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens

Dobias, Jan ; Dénervaud-Tendon, Valérie ; Poirel, Laurent ; Nordmann, Patrice

In: European Journal of Clinical Microbiology & Infectious Diseases, 2017, p. 1–9

The novel siderophore cephalosporin cefiderocol (S-649266) with potent activity against Gram-negative pathogens was recently developed (Shionogi & Co., Ltd.). Here, we evaluated the activity of this new molecule and comparators against a collection of previously characterized Gram-negative isolates using broth microdilution panels. A total of 753 clinical multidrug-resistant Gram-negative...

Integration of the blaNDM-1 carbapenemase gene into Proteus genomic island 1 (PGI1-PmPEL) in a Proteus mirabilis clinical isolate

Girlich, Delphine ; Dortet, Laurent ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 1, p. 98-102