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Université de Fribourg

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

Brügger, Valérie ; Duman, Mert ; Bochud, Maëlle ; Münger, Emmanuelle ; Heller, Manfred ; Ruff, Sophie ; Jacob, Claire

In: Nature Communications, 2017, vol. 8, p. 14272

The peripheral nervous system (PNS) regenerates after injury. However, regeneration is often compromised in the case of large lesions, and the speed of axon reconnection to their target is critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that foster axonal regrowth, and redifferentiate to rebuild myelin. These processes require...

Université de Fribourg

The role of the cognitive control system in recovery from bilingual aphasia: a multiple single-case fMRI study

Radman, Narges ; Mouthon, Michael ; Pietro, Marie Di ; Gaytanidis, Chrisovalandou ; Leemann, Beatrice ; Abutalebi, Jubin ; Annoni, Jean-Marie

In: Neural Plasticity, 2016, vol. 2016, p. e8797086

Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture...