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Consortium of Swiss Academic Libraries

Deep neck space abscesses of dental origin: the impact of Streptococcus group Milleri

Terzic, Andrej ; Scolozzi, Paolo

In: European Archives of Oto-Rhino-Laryngology, 2014, vol. 271, no. 10, p. 2771-2774

Université de Fribourg

In vitro and in vivo characterization of noso-502, a novel inhibitor of bacterial translation

Racine, Emilie ; Nordmann, Patrice ; Pantel, Lucile ; Sarciaux, Matthieu ; Serri, Marine ; Houard, Jessica ; Villain-Guillot, Philippe ; Demords, Anthony ; Lundberg, Carina Vingsbo ; Gualtieri, Maxime

In: Antimicrobial Agents and Chemotherapy, 2018, vol. 62, no. 9, p. e01016-18

Antibacterial activity screening of a collection of Xenorhabdus strains led to the discovery of the odilorhabdins, a new antibiotic class with broad-spectrum activity against Gram-positive and Gram-negative pathogens. Odilorhabdins inhibit bacterial translation by a new mechanism of action on ribosomes. A lead optimization program identified NOSO-502 as a promising candidate. NOSO-502 has MIC...