In: Current Biology, 2020, vol. 30, no. 19, p. 3775-3787.e7
Sphingolipids play important roles in physiology and cell biology, but a systematic examination of their functions is lacking. We performed a genome-wide CRISPRi screen in sphingolipid-depleted human cells and identified hypersensitive mutants in genes of membrane trafficking and lipid biosynthesis, including ether lipid synthesis. Systematic lipidomic analysis showed a coordinate regulation...
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In: Journal of Colloid and Interface Science, 2020, vol. 562, p. 502–510
The aqueous channel size of lipidic cubic phases can be a limiting factor for certain applications. For this reason, additives have been used to exquisitely control their nanostructure. In this study, two families of primary phosphoesters have been designed, synthesised and utilised to determine the effect of the positioning of the guest additive at the interface of the host mesophase, and to...
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In: Accounts of Chemical Research, 2019, vol. 52, no. 11, p. 3087–3096
The regulatory chemical mechanisms of lipid trafficking and degradation are involved in many pathophysiological processes, being implicated in severe pain, inflammation, and cancer. In addition, the processing of lipids is also relevant for industrial and environmental applications. However, there is poor understanding of the chemical features that control lipid membrane trafficking and allow...
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In: Journal of Low Temperature Physics, 2014, vol. 175, no. 5-6, p. 784-798
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In: Explaining communication : contemporary theories and exemplars, 2007, p. 293-310
Communication Accommodation Theory (CAT) provides a wide-ranging framework aimed at predicting and explaining many of the adjustments individuals make to create, maintain,or decrease social distance in interaction. It explores the different ways in which we accommodate our communication, our motivations for doing so, and the consequences. CAT addresses interpersonal communication issues, yet...
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In: Scientific Reports, 2017, vol. 7, no. 1, p. 15310
Tick-borne relapsing fever (RF) borreliosis is a neglected disease that is often misdiagnosed. RF species circulating in the United States include Borrelia turicatae, which is transmitted by argasid ticks. Environmental adaptation by RF Borrelia is poorly understood, however our previous studies indicated differential regulation of B. turicatae genes localized on the 150 kb linear...
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In: Journal of Petrology, 2010, vol. 51, no. 9, p. 1783-1830
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In: Geophysical Journal International, 2003, vol. 155, no. 1, p. 11-32
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In: Transactions of the Royal Society of Edinburgh: Earth Sciences, 1992, vol. 83, no. 1-2, p. 361-375
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In: Journal of Fluid Mechanics, 2014, vol. 752, p. 157-183
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