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Université de Fribourg

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions

Marques, Filipe ; Thapliyal, Saurabh ; Javer, Avelino ; Shrestha, Priyanka ; Brown, André E. X. ; Glauser, Dominique A.

In: PLOS Genetics, 2020, vol. 16, no. 10, p. e1009102

Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, invertebrate genomes contain a single RyR-encoding gene and it has long been proposed that different transcripts generated by alternative splicing may diversify...

Université de Fribourg

Parasite‐driven replacement of a sexual by a closely related asexual taxon in nature

Lohr, Jennifer N. ; Haag, Christoph R.

In: Ecology, 2020, vol. 101, no. 10, p. -

Asexual species are thought to suffer more from coevolving parasites than related sexuals. Yet a variety of studies do not find the patterns predicted by theory. Here, to shine light on this conundrum, we investigate one such case of an asexual advantage in the presence of parasites. We follow the frequency dynamics of sexual and asexual Daphnia pulex in a natural pond that was initially...

Université de Fribourg

Inference of natural selection from ancient DNA

Dehasque, Marianne ; Ávila‐Arcos, María C. ; Díez‐del‐Molino, David ; Fumagalli, Matteo ; Guschanski, Katerina ; Lorenzen, Eline D. ; Malaspinas, Anna‐Sapfo ; Marques‐Bonet, Tomas ; Martin, Michael D. ; Murray, Gemma G. R. ; Papadopulos, Alexander S. T. ; Therkildsen, Nina Overgaard ; Wegmann, Daniel ; Dalén, Love ; Foote, Andrew D.

In: Evolution Letters, 2020, vol. 4, no. 2, p. 94–108

Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. Sequencing ancient DNA from temporally spaced samples can inform about past selection processes, as time series data allow direct...

Université de Fribourg

Electron–phonon-driven three-dimensional metallicity in an insulating cuprate

Baldini, Edoardo ; Sentef, Michael A. ; Acharya, Swagata ; Brumme, Thomas ; Sheveleva, Evgeniia ; Lyzwa, Fryderyk ; Pomjakushina, Ekaterina ; Bernhard, Christian ; van Schilfgaarde, Mark ; Carbone, Fabrizio ; Rubio, Angel ; Weber, Cédric

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 12, p. 6409-6416

The role of the crystal lattice for the electronic properties of cuprates and other high-temperature superconductors remains controversial despite decades of theoretical and experimental efforts. While the paradigm of strong electronic correlations suggests a purely electronic mechanism behind the insulator-to-metal transition, recently the mutual enhancement of the electron–electron and the...

Université de Fribourg

Alleviating the sign problem in quantum Monte Carlo simulations of spin-orbit-coupled multiorbital Hubbard models

Kim, Aaram J. ; Werner, Philipp ; Valentí, Roser

In: Physical Review B, 2020, vol. 101, no. 4, p. 045108

We present a strategy to alleviate the sign problem in continuous-time quantum Monte Carlo (CTQMC) simulations of the dynamical-mean-field-theory (DMFT) equations for the spin-orbit-coupled multiorbital Hubbard model. We first identify the combinations of rotationally invariant Hund coupling terms present in the relativistic basis which lead to a severe sign problem. Exploiting the fact that...