In: Bioinformatics, 2017, vol. 33, no. 21, p. 3454-3460
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In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 3, p. -
Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315),...
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In: Cell reports, 2020, vol. 32, no. 9, p. 12 p
Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...
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In: Nature Communications, 2019, vol. 10, no. 1, p. 1–16
ON and OFF selectivity in visual processing is encoded by parallel pathways that respond to either light increments or decrements. Despite lacking the anatomical features to support split channels, Drosophila larvae effectively perform visually- guided behaviors. To understand principles guiding visual computation in this simple circuit, we focus on investigating the physiological properties...
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In: Plos one, 2017, vol. 12, no. 10, p. e0186854
Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)—a highly prevalent childhood pathogen without a licensed vaccine—we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F) “DS-Cav1” immunogen, which induced high titer...
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In: Npj vaccines, 2017, vol. 2, p. 7
Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered that stabilize the metastable fusion (F) glycoprotein in its prefusion state; however, the absence of a relevant animal model for human RSV has complicated...
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In: Physical Review Letters, 2018, vol. 120, no. 13, p. 136404
The transition metal dichalcogenide 1T−TiSe2-two-dimensional layered material undergoing a commensurate 2×2×2 charge density wave (CDW) transition with a weak periodic lattice distortion (PLD) below ≈200 K. Scanning tunneling microscopy (STM) combined with intentionally introduced interstitial Ti atoms allows us to go beyond the usual spatial resolution of STM and to intimately probe...
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In: Applicable Algebra in Engineering, Communication and Computing, 2008, vol. 19, no. 3, p. 229-239
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In: Biological Cybernetics, 2008, vol. 99, no. 4-5, p. 303-318
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In: GeoInformatica, 2008, vol. 12, no. 3, p. 357-376
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