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Università della Svizzera italiana

Within-host evolution results in antigenically distinct GII.4 noroviruses

Debbink, Kari ; Lindesmith, Lisa C. ; Ferris, Martin T. ; Swanstrom, Jesica ; Beltramello, Martina ; Corti, Davide ; Lanzavecchia, Antonio ; Baric, Ralph S.

In: Journal of virology, 2014, vol. 88, no. 13, p. 7244–7255

Genogroup II, genotype 4 (GII.4) noroviruses are known to rapidly evolve, with the emergence of a new primary strain every 2 to 4 years as herd immunity to the previously circulating strain is overcome. Because viral genetic diversity is higher in chronic than in acute infection, chronically infected immunocompromised people have been hypothesized to be a potential source for new epidemic...

Université de Fribourg

The diversity of population responses to environmental change

Colchero, Fernando ; Jones, Owen R. ; Conde, Dalia A. ; Hodgson, David ; Zajitschek, Felix ; Schmidt, Benedikt R. ; Malo, Aurelio F. ; Alberts, Susan C. ; Becker, Peter H. ; Bouwhuis, Sandra ; Bronikowski, Anne M. ; Vleeschouwer, Kristel M. ; Delahay, Richard J. ; Dummermuth, Stefan ; Fernández‐Duque, Eduardo ; Frisenvænge, John ; Hesselsøe, Martin ; Larson, Sam ; Lemaître, Jean‐François ; McDonald, Jennifer ; Miller, David A.W. ; O'Donnell, Colin ; Packer, Craig ; Raboy, Becky E. ; Reading, Chris J. ; Wapstra, Erik ; Weimerskirch, Henri ; While, Geoffrey M. ; Baudisch, Annette ; Flatt, Thomas ; Coulson, Tim ; Gaillard, Jean‐Michel

In: Ecology Letters, 2019, p. -

The current extinction and climate change crises pressure us to predict population dynamics with ever‐greater accuracy. Although predictions rest on the well‐advanced theory of age‐structured populations, two key issues remain poorly explored. Specifically, how the age‐dependency in demographic rates and the year‐to‐year interactions between survival and fecundity affect...

Université de Fribourg

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Capogrosso, Marco ; Wagner, Fabien B. ; Gandar, Jerome ; Moraud, Eduardo Martin ; Wenger, Nikolaus ; Milekovic, Tomislav ; Shkorbatova, Polina ; Pavlova, Natalia ; Musienko, Pavel ; Bezard, Erwan ; Bloch, Jocelyne ; Courtine, Grégoire

In: Nature Protocols, 2018, vol. 13, no. 9, p. 2031–2061

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted...