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Université de Fribourg

Changing the light schedule in late pregnancy alters birth timing in mice

Amano, Tomoko ; Ripperger, Jürgen A. ; Albrecht, Urs

In: Theriogenology, 2020, vol. 154, p. 212–222

In rats, birth timing is affected by changes in the light schedule until the middle of the pregnancy period. This phenomenon can be used to control birth timing in the animal industry and/or clinical fields. However, changes in the light schedule until the middle of the pregnancy period can damage the fetus by affecting the development of the major organs. Thus, we compared birth timing in...

Université de Fribourg

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

Brenna, Andrea ; Olejniczak, Iwona ; Chavan, Rohit ; Ripperger, Jürgen A. ; Langmesser, Sonja ; Cameroni, Elisabetta ; Hu, Zehan ; De Virgilio, Claudio ; Dengjel, Jörn ; Albrecht, Urs

In: eLife, 2019, vol. 8, p. e50925

Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5...

Université de Fribourg

Laughter is in the air: Involvement of key nodes of the emotional motor system in the anticipation of tickling

Wattendorf, Elise ; Westermann, Birgit ; Fiedler, Klaus ; Ritz, Simone ; Redmann, Annetta ; Pfannmöller, Jörg ; Lotze, Martin ; Celio, Marco R

In: Social Cognitive and Affective Neuroscience, 2019, p. -

In analogy to the appreciation of humor, that of tickling is based upon the re- interpretation of an anticipated emotional situation. Hence, the anticipation of tickling contributes to the final outburst of ticklish laughter. To localize the neuronal substrates of this process, fMRI was conducted on 31 healthy volunteers. The state of anticipation was simulated by generating an uncertainty...

Université de Fribourg

Circadian clocks and sleep: impact of rhythmic metabolism and waste clearance on the brain

Albrecht, Urs ; Ripperger, Jürgen A.

In: Trends in Neurosciences, 2018, vol. 41, no. 10, p. 677–688

The rotation of the Earth around its axis causes periodic exposure of half of its surface to sunlight. This daily recurring event has been internalized in most organisms in the form of cellular circadian clock mechanisms. These cellular clocks are synchronized with each other in various ways to establish circadian networks that build the circadian program in tissues and organs, coordinating...

Université de Fribourg

Age-dependent adaptations to anticipated and non-anticipated perturbations after balance training in children

Wälchli, Michael ; Keller, Martin ; Ruffieux, Jan ; Mouthon, Audrey ; Taube, Wolfgang

In: Human Movement Science, 2018, vol. 59, p. 170–177

Postural control undergoes rapid changes during child development. However, the influence of balance training (BT) on the compensation of perturbations has not yet been investigated in children. For this purpose, young (6.7 ± 0.6 years) and old children (12.0 ± 0.4 years) were exposed to externally induced anticipated (direction known) and non-anticipated (direction unknown)...

Università della Svizzera italiana

Journalists arguing newsmaking decisions on the basis of anticipated audience uptake : a study of argumentation in the newsroom

Luciani, Margherita ; Rocci, Andrea (Dir.) ; Perrin, Daniel (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018COM006.

This thesis sets out to explore journalists’ anticipatory reasoning on audience uptake, i.e. on the ways in which the audience will react to news. In order to reach this goal, I conduct an argumentative analysis of various types of newsroom activities. The analysis sheds light on journalists’ reasoning processes concerning audience uptake that lead them to broadcast/publish one certain...