Université de Fribourg

Phosphorylation and circadian molecular timing

Brenna, Andrea ; Albrecht, Urs

In: Frontiers in Physiology, 2020, vol. 11, p. -

Endogenous circadian rhythms are biological processes generated by an internal body clock. They are self-sustaining, and they govern biochemical and physiological processes. However, circadian rhythms are influenced by many external stimuli to reprogram the phase in response to environmental change. Through their adaptability to environmental changes, they synchronize physiological responses...

Université de Fribourg

Circadian and genetic modulation of visually-guided navigation in Drosophila larvae

Asirim, Ece Z. ; Humberg, Tim-Henning ; Maier, G. Larisa ; Sprecher, Simon G.

In: Scientific Reports, 2020, vol. 10, no. 1, p. 2752

Organisms possess an endogenous molecular clock which enables them to adapt to environmental rhythms and to synchronize their metabolism and behavior accordingly. Circadian rhythms govern daily oscillations in numerous physiological processes, and the underlying molecular components have been extensively described from fruit flies to mammals. Drosophila larvae have relatively simple nervous...

Université de Fribourg

Changing the light schedule in late pregnancy alters birth timing in mice

Amano, Tomoko ; Ripperger, Jürgen A. ; Albrecht, Urs

In: Theriogenology, 2020, vol. 154, p. 212–222

In rats, birth timing is affected by changes in the light schedule until the middle of the pregnancy period. This phenomenon can be used to control birth timing in the animal industry and/or clinical fields. However, changes in the light schedule until the middle of the pregnancy period can damage the fetus by affecting the development of the major organs. Thus, we compared birth timing in...

Université de Fribourg

Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2020, vol. 37, p. 70–81

Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. However, the exact role of let-7d miRNA in regulating ethanol intake and preference remains to be elucidated. The aim of the present study was to clarify the role of accumbal let-7d in controlling...

Université de Fribourg

Molecular connections between circadian clocks and mood-related behaviors

Albrecht, Urs

In: Journal of Molecular Biology, 2020, vol. 432, no. 12, p. 3714–3721

The circadian system consists of individual cellular clocks. It organizes and synchronizes biochemical and physiological processes in order to optimally adapt an organism to its environment. This requires that the circadian system is responsive to environmental cues, which contain information about geophysical time (e.g., light), and allows an organism to predict daily recurring events....

Université de Fribourg

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Psychopharmacology, 2019, p. -

During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alcoholism. On the other hand, environmental enrichment (EE) has a neuroprotective role...