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Università della Svizzera italiana

Thioredoxin-related transmembrane proteins : TMX1 and little brothers TMX2, TMX3, TMX4 and TMX5

Guerra, Concetta ; Molinari, Maurizio

In: Cells, 2020, vol. 9, no. 9, p. 11 p

The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members of the Protein Disulfide Isomerase (PDI) family. These enzymes regulate formation, isomerization and disassembly of covalent bonds between cysteine residues. As such, PDIs ensure protein folding, which is required to attain functional...

Università della Svizzera italiana

Redox-mediated mechanisms fuel monocyte responses to CXCL12/HMGB1 in active rheumatoid arthritis

Cecchinato, Valentina ; D'Agostino, Gianluca ; Raeli, Lorenzo ; Nerviani, Alessandra ; Schiraldi, Milena ; Danelon, Gabriela ; Manzo, Antonio ; Thelen, Marcus ; Ciurea, Adrian ; Bianchi, Marco E. ; Rubartelli, Anna ; Pitzalis, Costantino ; Uguccioni, Mariagrazia

In: Frontiers in immunology, 2018, vol. 9, p. 2118

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, initiates a cascade of events leading to production of cytokines and chemokines. So far, the...

Université de Fribourg

Vectorial import via a metastable disulfide-linked complex allows for a quality control step and import by the mitochondrial disulfide relay

Habich, Markus ; Salscheider, Silja Lucia ; Murschall, Lena Maria ; Hoehne, Michaela Nicole ; Fischer, Manuel ; Schorn, Fabian ; Petrungaro, Carmelina ; Ali, Muna ; Erdogan, Alican J. ; Abou-Eid, Shadi ; Kashkar, Hamid ; Dengjel, Jörn ; Riemer, Jan

In: Cell Reports, 2019, vol. 26, no. 3, p. 759-774.e5

Disulfide formation in the mitochondrial intermembrane space (IMS) is an essential process. It is catalyzed by the disulfide relay machinery, which couples substrate import and oxidation. The machinery relies on the oxidoreductase and chaperone CHCHD4-Mia40. Here, we report on the driving force for IMS import and on a redox quality control mechanism. We demonstrate that unfolded reduced...

Consortium of Swiss Academic Libraries

Changing concepts in plant hormone action

Gaspar, Th ; Kevers, C. ; Faivre-Rampant, O. ; Crèvecoeur, M. ; Penel, CL ; Greppin, H. ; Dommes, J.

In: In Vitro Cellular & Developmental Biology - Plant, 2003, vol. 39, no. 2, p. 85-106

Consortium of Swiss Academic Libraries

nDsbD: a redox interaction hub in the Escherichia coli periplasm

Stirnimann, C. ; Grütter, M. ; Glockshuber, R. ; Capitani, G.

In: Cellular and Molecular Life Sciences CMLS, 2006, vol. 63, no. 14, p. 1642-1648

Université de Neuchâtel

Chloroplast lipid droplet type II NAD(P)H oxidoreductase, NDC1, is essential for vitamin E and K1 metabolism

Eugeni Piller, Lucia ; Kessler, Felix (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

Plant cells in different tissues contain specialized organelles belonging to the family of plastids. The chloroplast is the most prominent family member and responsible for photosynthesis in leaves. Most plastid types contain lipoprotein particles ("lipid droplets") termed plastoglobules. Little is known about plastoglobules that were long regarded as passive storage droplets. Indeed, the...