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Université de Fribourg

GPCR-based dopamine sensors—a detailed guide to inform sensor choice for in vivo imaging

Labouesse, Marie A. ; Cola, Reto B. ; Patriarchi, Tommaso

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 21, p. 8048

Understanding how dopamine (DA) encodes behavior depends on technologies that can reliably monitor DA release in freely-behaving animals. Recently, red and green genetically encoded sensors for DA (dLight, GRAB-DA) were developed and now provide the ability to track release dynamics at a subsecond resolution, with submicromolar affinity and high molecular specificity. Combined with rapid ...

Université de Fribourg

Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2020, vol. 37, p. 70–81

Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. However, the exact role of let-7d miRNA in regulating ethanol intake and preference remains to be elucidated. The aim of the present study was to clarify the role of accumbal let-7d in controlling...

Université de Fribourg

Reward-related behavioral and biological responses associated with eating : insights from anorexia nervosa and obesity research = Réponses bio-comportementales liées à la récompense: aperçus de la recherche en anorexie mentale et en obésité

Pereira Picolo Ribeiro, Mayron ; Martin Soelch, Chantal (Dir.)

Thèse de doctorat : Université de Fribourg, 2020.

Research on clinical populations with eating disturbances has shown the involvement of reward processing in the maintenance of disease- associated symptoms. Investigation on food as a reward indicates the metabolic or feeding state (i.e. fasted or fed state) as a modulator of food as a reward, but little is known about how these states influence other types of reward. This is important...

Université de Fribourg

Food vs money? Effects of hunger on mood and behavioral reactivity to reward in anorexia nervosa

Piccolo, Mayron ; Milos, Gabriella ; Bluemel, Sena ; Schumacher, Sonja ; Müller-Pfeiffer, Christoph ; Fried, Michael ; Ernst, Monique ; Martin-Soelch, Chantal

In: Appetite, 2019, vol. 134, p. 26-33

BACKGROUND: Previous studies using neuroimaging and behavioral measures reported altered reward processing in anorexia nervosa (AN). In addition, anhedonia states are frequently reported in AN, potentially due to the physiological stress produced by the permanent starvation. We investigated the effect of fasting and satiety on mood and reaction times to monetary rewards in AN patients and healthy...

Consortium of Swiss Academic Libraries

A survey of uncertainty principles and some signal processing applications

Ricaud, Benjamin ; Torrésani, Bruno

In: Advances in Computational Mathematics, 2014, vol. 40, no. 3, p. 629-650