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Université de Fribourg

Circadian and genetic modulation of visually-guided navigation in Drosophila larvae

Asirim, Ece Z. ; Humberg, Tim-Henning ; Maier, G. Larisa ; Sprecher, Simon G.

In: Scientific Reports, 2020, vol. 10, no. 1, p. 2752

Organisms possess an endogenous molecular clock which enables them to adapt to environmental rhythms and to synchronize their metabolism and behavior accordingly. Circadian rhythms govern daily oscillations in numerous physiological processes, and the underlying molecular components have been extensively described from fruit flies to mammals. Drosophila larvae have relatively simple nervous...

Università della Svizzera italiana

Experiential learning under ambiguity

Wahle, Thorsten ; Martignoni, Dirk (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020ECO003.

In this dissertation I study choice contexts of learning under ambiguity. Experiential learning takes place by making choices, observing the outcomes, and altering future choices accordingly. Over time, such learning is expected to improve choices and outcomes but only when decision makers can classify outcomes as either successes or failures. This dichotomous outcome has clear behavioral...

Université de Fribourg

Life-history evolution and the genetics of fitness components in drosophila melanogaster

Flatt, Thomas

In: Genetics, 2020, vol. 214, no. 1, p. 3–48

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span—are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding of adaptation. Due to its simple and rapid life cycle, cosmopolitan...

Université de Fribourg

Wolbachia modifies thermal preference in Drosophila melanogaster

Truitt, Amy M. ; Kapun, Martin ; Kaur, Rupinder ; Miller, Wolfgang J.

In: Environmental Microbiology, 2019, vol. 21, no. 9, p. 3259–3268

Environmental variation can have profound and direct effects on fitness, fecundity, and host–symbiont interactions. Replication rates of microbes within arthropod hosts, for example, are correlated with incubation temperature but less is known about the influence of host–symbiont dynamics on environmental preference. Hence, we conducted thermal preference (Tp) assays and tested if...

Université de Fribourg

Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila

Hoedjes, Katja M. ; van den Heuvel, Joost ; Kapun, Martin ; Keller, Laurent ; Flatt, Thomas ; Zwaan, Bas J.

In: Evolution Letters, 2019, p. -

Reproduction and diet are two major factors controlling the physiology of aging and life history, but how they interact to affect the evolution of longevity is unknown. Moreover, although studies of large‐effect mutants suggest an important role of nutrient sensing pathways in regulating aging, the genetic basis of evolutionary changes in lifespan remains poorly understood. To address these...

Université de Fribourg

Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly

May, Christina M. ; Heuvel, Joost van den ; Doroszuk, Agnieszka ; Hoedjes, Katja M. ; Flatt, Thomas ; Zwaan, Bas J.

In: Journal of Evolutionary Biology, 2019, vol. 32, no. 5, p. 425–437

Experimental evolution (EE) is a powerful tool for addressing how environmental factors influence life‐history evolution. While in nature different selection pressures experienced across the lifespan shape life histories, EE studies typically apply selection pressures one at a time. Here, we assess the consequences of adaptation to three different developmental diets in combination with...

Université de Fribourg

The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster

Kapun, Martin ; Flatt, Thomas

In: Molecular Ecology, 2019, vol. 28, no. 6, p. 1263–1282

Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or ...

Université de Fribourg

Host range and Specificity of the Drosophila C Virus

Kapun, Martin ; Nolte, Viola ; Flatt, Thomas ; Schlötterer, Christian

In: PLoS ONE, 2010, vol. 5, no. 8, p. 1-5

Background: The Drosophila C virus (DCV) is a common and well-studied Drosophila pathogen. Although natural infections are known from Drosophila melanogaster and D. simulans, and artificial infections have been reported from several. Drosophila species and other insects, it remains unclear to date whether DCV infections also occur naturally in other Drosophila species. Methods/Principal Findings:...