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Université de Fribourg

Cross-border emergence of clonal lineages of ST38 Escherichia coli producing the OXA-48-like carbapenemase OXA-244 in Germany and Switzerland

Falgenhauer, Linda ; Nordmann, Patrice ; Imirzalioglu, Can ; Yao, Yancheng ; Falgenhauer, Jane ; M.Hauri, Anja ; Heinmüller, Petra ; Chakraborty, Trinad

In: International Journal of Antimicrobial Agents, 2020, vol. 56, no. 6, p. 106157

Background: Carbapenemase-producing Gram-negative bacteria cause infections that are difficult to treat and represent a rising threat to healthcare systems worldwide. This study analysed isolates of Escherichia coli (E. coli), a species associated with nosocomial-acquired and community-acquired infections, from hospitals in Germany and Switzerland exhibiting a slight decrease in...

Université de Fribourg

Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany

Chakraborty, Trinad ; Sadek, Mustafa ; Yao, Yancheng ; Imirzalioglu, Can ; Stephan, Roger ; Poirel, Laurent ; Nordmann, Patrice

In: Journal of Clinical Microbiology, 2020, p. -

A series of clinical NDM-5-producing E. coli isolates obtained from two surveillance networks of carbapenem-producing Enterobacterales from 2018-2019, namely Switzerland (NARA) and Germany (SurvCARE), were analyzed. The 33 NDM-5- producing E. coli isolates were highly resistant to β-lactams including the novel ß- lactam/ß-lactamase inhibitor combinations (ceftazidime/avibactam, ...

Université de Fribourg

Draft genome sequences of multidrug-resistant acinetobacter sp. strains from colombian hospitals

Barreto-Hernández, Emiliano ; Falquet, Laurent ; Reguero, María T. ; Mantilla, José R. ; Valenzuela, Emilia M. ; González, Elsa ; Cepeda, Alexandra ; Escalante, Andrea

In: Genome Announcements, 2013, vol. 1, no. 6, p. -

The draft genome sequences of the strains Acinetobacter baumannii 107m, Acinetobacter nosocomialis 28F, and Acinetobacter pittii 42F, isolated from Colombian hospitals, are reported here. These isolates are causative of nosocomial infections and are classified as multidrug resistant, as they showed resistance to four different antibiotic groups.

Université de Fribourg

Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases

Piza-Buitrago, Adriana ; Rincón, Verónica ; Donato, John ; Saavedra, Sandra Yamile ; Duarte, Carolina ; Morero, Jaime ; Falquet, Laurent ; Reguero, María Teresa ; Barreto-Hernández, Emiliano

In: BMC Microbiology, 2020, vol. 20, no. 1, p. 345

Providencia rettgeri is a nosocomial pathogen associated with urinary tract infections and related to Healthcare-Associated Infection (HAI). In recent years isolates producing New Delhi Metallo-β-lactamase (NDM) and other β-lactamases have been reported that reduce the efficiency of clinical antimicrobial treatments. In this study, we analyzed antibiotic resistance, the presence of...

Université de Fribourg

First genomic characterization of blavim-1 and mcr-9-coharbouring enterobacter hormaechei isolated from food of animal origin

Sadek, Mustafa ; Nariya, Hirofumi ; Shimamoto, Toshi ; Kayama, Shizuo ; Yu, Liansheng ; Hisatsune, Junzo ; Sugai, Motoyuki ; Nordmann, Patrice ; Poirel, Laurent ; Shimamoto, Tadashi

In: Pathogens, 2020, vol. 9, no. 9, p. 687

We describe here the complete genome sequence of an Enterobacter hormaechei ST279 coharbouring blaVIM-1 and mcr-9 recovered from uncooked beef patty in June 2017, Egypt. The tested isolate was resistant to carbapenem but susceptible to colistin (minimum inhibitory concentration (MIC), 0.5 μg/mL). The antimicrobial susceptibility profile and conjugation experiments were performed. The entire...

Université de Fribourg

Draft genome sequence of a blaNDM-1- and blaOXA-244-carrying multidrug-resistant Escherichia coli D-ST69 clinical isolate from Egypt

Soliman, Ahmed M. ; Ramadan, Hazem ; Sadek, Mustafa ; Nariya, Hirofumi ; Shimamoto, Toshi ; Hiott, Lari M. ; Frye, Jonathan G. ; Jackson, Charlene R. ; Shimamoto, Tadashi

In: Journal of Global Antimicrobial Resistance, 2020, vol. 22, p. 832–834

Objectives: This study describes the first draft genome sequence of a multidrug- resistant (MDR) Escherichia coli D-ST69 clinical isolate from Egypt carrying blaNDM-1 and blaOXA-244.Methods: The strain was isolated in December 2014 from a wound pus swab of a male patient in the city of Kafr El-Sheikh using MacConkey agar containing 2 μg/mL meropenem. The strain was subjected to antimicrobial ...

Université de Fribourg

Ongoing dissemination of OXA-244 carbapenemase-producing Escherichia coli in Switzerland and their detection

Masseron, Amandine ; Poirel, Laurent ; Falgenhauer, Linda ; Imirzalioglu, Can ; Kessler, Julie ; Chakraborty, Trinad ; Nordmann, Patrice

In: Diagnostic Microbiology and Infectious Disease, 2020, vol. 97, no. 3, p. 115059

OXA-244 is a derivative of OXA-48 showing weaker carbapenemase activity, compromising the detection of corresponding producers in clinical laboratories. Since 2017, the Swiss National Reference Center for Emerging Antibiotic Resistance noticed an increased identification of OXA-244-producing Escherichia coli (n=15) within the country. Different methods (biochemical and immunoassay tests,...

Université de Fribourg

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...