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Università della Svizzera italiana

Marine anticancer agents : an overview with a particular focus on their chemical classes

Barreca, Marilia ; Spanò, Virginia ; Montalbano, Alessandra ; Cueto, Mercedes ; Díaz Marrero, Ana R. ; Deniz, Irem ; Erdoğan, Ayşegül ; Lukić Bilela, Lada ; Moulin, Corentin ; Taffin-de-Givenchy, Elisabeth ; Spriano, Filippo ; Perale, Giuseppe ; Mehiri, Mohamed ; Rotter, Ana ; Thomas, Olivier P. ; Barraja, Paola ; Gaudêncio, Susana P. ; Bertoni, Francesco

In: Marine drugs, 2020, vol. 18, no. 12, p. 28

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...

Université de Fribourg

Design and characterization of bio-inspired antimicrobial nanomaterials

Zabara, Mahsa ; Hong, Linda ; Salentinig, Stefan

In: CHIMIA International Journal for Chemistry, 2020, vol. 74, no. 9, p. 674–680

Colloidal structures are crucial components in biological systems and provide a vivid and seemingly infinite source of inspiration for the design of functional bio-inspired materials. They form multi-dimensional confinements and shape living matter, and transport and protect bioactive molecules in harsh biological environments such as the stomach. Recently, colloidal nanostructures based on...

Université de Fribourg

Misfit layer compounds: a platform for heavily doped 2D transition metal dichalcogenides

Leriche, Raphaël T. ; Palacio‐Morales, Alexandra ; Campetella, Marco ; Tresca, Cesare ; Sasaki, Shunsuke ; Brun, Christophe ; Debontridder, François ; David, Pascal ; Arfaoui, Imad ; Šofranko, Ondrej ; Samuely, Tomas ; Kremer, Geoffroy ; Monney, Claude ; Jaouen, Thomas ; Cario, Laurent ; Calandra, Matteo ; Cren, Tristan

In: Advanced Functional Materials, 2020, p. 2007706

Transition metal dichalcogenides (TMDs) display a rich variety of instabilities such as spin and charge orders, Ising superconductivity, and topological properties. Their physical properties can be controlled by doping in electric double‐layer field‐effect transistors (FET). However, for the case of single layer NbSe2, FET doping is limited to ≈1 × 1014 cm−2, while a somewhat larger...

Université de Fribourg

Transition from light diffusion to localization in three-dimensional amorphous dielectric networks near the band edge

Haberko, Jakub ; Froufe-Pérez, Luis S. ; Scheffold, Frank

In: Nature Communications, 2020, vol. 11, no. 1, p. 4867

AbstractLocalization of light is the photon analog of electron localization in disordered lattices, for whose discovery Anderson received the Nobel prize in 1977. The question about its existence in open three-dimensional materials has eluded an experimental and full theoretical verification for decades. Here we study numerically electromagnetic vector wave transmittance through realistic...

Université de Fribourg

Structural phase transition and bandgap control through mechanical deformation in layered semiconductors 1T–ZrX2 (X = S, Se)

Martino, Edoardo ; Santos-Cottin, David ; Le Mardelé, Florian ; Semeniuk, Konstantin ; Pizzochero, Michele ; Čerņevičs, Kristia̅ns ; Baptiste, Benoît ; Delbes, Ludovic ; Klotz, Stefan ; Capitani, Francesco ; Berger, Helmuth ; Yazyev, Oleg V. ; Akrap, Ana

In: ACS Materials Letters, 2020, vol. 2, no. 9, p. 1115–1120

Applying elastic deformation can tune a material’s physical properties locally and reversibly. Spatially modulated lattice deformation can create a bandgap gradient, favoring photogenerated charge separation and collection in optoelectronic devices. These advantages are hindered by the maximum elastic strain that a material can withstand before breaking. Nanomaterials derived by exfoliating...

Université de Fribourg

Cenozoic evolution of the steppe-desert biome in Central Asia

Barbolini, N. ; Woutersen, A. ; Dupont-Nivet, G. ; Silvestro, Daniele ; Tardif, D. ; Coster, P. M. C. ; Meijer, N. ; Chang, C. ; Zhang, H.-X. ; Licht, A. ; Rydin, C. ; Koutsodendris, A. ; Han, F. ; Rohrmann, A. ; Liu, X.-J. ; Zhang, Y. ; Donnadieu, Y. ; Fluteau, F. ; Ladant, J.-B. ; Le Hir, G. ; Hoorn, C.

In: Science Advances, 2020, vol. 6, no. 41, p. eabb8227

The origins and development of the arid and highly seasonal steppe-desert biome in Central Asia, the largest of its kind in the world, remain largely unconstrained by existing records. It is unclear how Cenozoic climatic, geological, and biological forces, acting at diverse spatial and temporal scales, shaped Central Asian ecosystems through time. Our synthesis shows that the Central Asian...

Université de Fribourg

Experimental tuning of transport regimes in hyperuniform disordered photonic materials

Aubry, Geoffroy J. ; Froufe-Pérez, Luis S. ; Kuhl, Ulrich ; Legrand, Olivier ; Scheffold, Frank ; Mortessagne, Fabrice

In: Physical Review Letters, 2020, vol. 125, no. 12, p. 127402

We present wave transport experiments in hyperuniform disordered arrays of cylinders with high dielectric permittivity. Using microwaves, we show that the same material can display transparency, photon diffusion, Anderson localization, or a full band gap, depending on the frequency ν of the electromagnetic wave. Interestingly, we find a second weaker band gap, which appears to be related to...

Université de Fribourg

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

Filseck, Joachim Moser von ; Čopič, Alenka ; Delfosse, Vanessa ; Vanni, Stefano ; Jackson, Catherine L. ; Bourguet, William ; Drin, Guillaume

In: Science, 2015, vol. 349, no. 6246, p. 432–436

In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...