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Université de Fribourg

Freely chosen cadence during cycling attenuates intracortical inhibition and increases intracortical facilitation compared to a similar fixed cadence

K.Sidhu, Simranjit ; Lauber, Benedikt

In: Neuroscience, 2020, vol. 441, p. 93–101

In contrast to other rhythmic tasks such as running, the preferred movement rate in cycling does not minimize energy consumption. It is possible that neurophysiological mechanisms contribute to the choice of cadence, however this phenomenon is not well understood. Eleven participants cycled at a fixed workload of 125 W and different cadences including a freely chosen cadence (FCC, ∼72),...

Université de Fribourg

Training‐, muscle‐ and task‐specific up‐ and downregulation of cortical inhibitory processes

Taube, Wolfgang ; Gollhofer, Albert ; Lauber, Benedikt

In: European Journal of Neuroscience, 2020, vol. 51, no. 6, p. 1428–1440

Motor cortical contribution was shown to be important for balance control and for ballistic types of movements. However, little is known about the role of cortical inhibitory mechanisms and even less about long(er)‐term adaptations of these inhibitory processes. Therefore, the aim of the present study was to investigate the role of intracortical inhibition before and after four weeks of ...

Université de Fribourg

Preconditioning cathodal transcranial direct current stimulation facilitates the neuroplastic effect of subsequent anodal transcranial direct current stimulation applied during cycling in young adults

Pourmajidian, Maryam ; Lauber, Benedikt ; Sidhu, Simranjit K

In: Neuroscience Letters, 2020, vol. 714, p. 134597

The study aimed to examine the effect of a pre-conditioning cathodal transcranial direct current stimulation (ctDCS) before subsequent anodal-tDCS (atDCS) was applied during low workload cycling exercise on the corticospinal responses in young healthy individuals. Eleven young subjects participated in two sessions receiving either conditioning ctDCS or sham stimulation, followed by atDCS...

Université de Fribourg

Assessment of the effect of continuous theta burst stimulation of the motor cortex on manual dexterity in non-human primates in a direct comparison with invasive intracortical pharmacological inactivation

Roux, Camille ; Kaeser, Mélanie ; Savidan, Julie ; Fregosi, Michela ; Rouiller, Eric M. ; Schmidlin, Eric

In: European Journal of Neuroscience, 2019, p. -

Non-invasive reversible perturbation techniques of brain output such as continuous theta burst stimulation (cTBS), commonly used to modulate cortical excitability in humans, allow investigation of possible roles in functional recovery played by distinct intact cortical areas following stroke. To evaluate the potential of cTBS, the behavioural effects of this non-invasive transient...

Université de Fribourg

Intracortical inhibition increases during postural task execution in response to balance training

Mouthon, Audrey ; Taube, Wolfgang

In: Neuroscience, 2019, vol. 401, p. 35–42

Intracortical inhibitory modulation seems crucial for an intact motor control and motor learning. However, the influence of long(er) term training on short-interval intracortical inhibition (SICI) is scarcely investigated. With respect to balance, it was previously shown that with increasing postural task difficulty, SICI decreased but the effect of balance training (BT) is unknown. The...

Université de Fribourg

Alterations in the cortical control of standing posture during varying levels of postural threat and task difficulty

Tokuno, Craig D. ; Keller, Martin ; Carpenter, Mark G. ; Márquez, Gonzalo ; Taube, Wolfgang

In: Journal of Neurophysiology, 2018, vol. 120, no. 3, p. 1010–1016

Cortical excitability increases during the performance of more difficult postural tasks. However, it is possible that changes in postural threat associated with more difficult tasks may in themselves lead to alterations in the neural strategies underlying postural control. Therefore, the purpose of this study was to examine whether changes in postural threat are responsible for the...