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Université de Fribourg

Molecular connections between circadian clocks and mood-related behaviors

Albrecht, Urs

In: Journal of Molecular Biology, 2020, vol. 432, no. 12, p. 3714–3721

The circadian system consists of individual cellular clocks. It organizes and synchronizes biochemical and physiological processes in order to optimally adapt an organism to its environment. This requires that the circadian system is responsive to environmental cues, which contain information about geophysical time (e.g., light), and allows an organism to predict daily recurring events....

Université de Fribourg

Increased anxiety after stimulation of the right inferior parietal lobe and the left orbitofrontal cortex

Grieder, Matthias ; Homan, Philipp ; Federspiel, Andrea ; Kiefer, Claus ; Hasler, Gregor

In: Frontiers in Psychiatry, 2020, vol. 11, p. -

Sustained anxiety is a key symptom of anxiety disorders and may be associated with neural activation in the right inferior parietal lobe (rIPL), particularly under unpredictable threat. This finding suggests a moderating role of the rIPL in sustained anxiety, which we tested in the current study. We applied cathodal or sham transcranial direct current stimulation (tDCS) to the rIPL as a...

Université de Fribourg

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina Evelyn ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horschg, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: NeuroImage: Clinical, 2020, vol. 26, p. 102193

Introduction: Anhedonia, a core symptom of Major Depressive Disorder (MDD), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. Exposure to stressful life events is another important risk factor for MDD. However, the mechanisms linking reward-deficit and stress to MDD remain poorly understood. Here,...

Haute Ecole de Santé Valais

Stress chez les étudiants en soins infirmiers : stratégies de coping en prévention : revue de la littérature

Grange, Alix ; Schär, Sabine (Dir.)

Mémoire de bachelor : Haute Ecole de Santé Valais, 2019.

Le stress et l’épuisement touchent de plus en plus d’étudiants infirmiers. Toutefois, peu d’études ont été réalisées sur le sujet, notamment en Suisse. De plus, les étudiants sont plus vulnérables face aux différents stresseurs et ont peu de connaissances sur les moyens pour y faire face. Les objectifs de ce travail sont d’explorer les facteurs de stress perçus, les stratégies...

Université de Fribourg

Striatal responsiveness to reward under threat‐of‐shock and working memory load : A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Torrisi, Salvatore ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina E. ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horsch, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: Brain and Behavior, 2019, no. 9, p. 1-21

Introduction: Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational...

Université de Fribourg

Reward processing under influence : Effects of stress and cognitive load on reward processing, and their clinical implications for the vulnerability to major depression

Gaillard, Claudie ; Martin Soelch, Chantal (Dir.)

Thèse de doctorat : Université de Fribourg, 2019.

Humans have a propensity to pursue rewards and to avoid punishments. The motivation to seek rewards and the ability to experience and to learn from positive consequences are fundamental functions in the reward processing. They promote survival and well-being. However, these functions can be challenged or impaired by stressful events or contexts. To clarify the determinant factors that might...