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Université de Fribourg

In vivo function of the lipid raft protein flotillin-1 during cd8+ t cell–mediated host surveillance

Ficht, Xenia ; Ruef, Nora ; Stolp, Bettina ; Samson, Guerric P. B. ; Moalli, Federica ; Page, Nicolas ; Merkler, Doron ; Nichols, Ben J. ; Diz-Muñoz, Alba ; Legler,, Daniel F. ; Niggli, Verena

In: The Journal of Immunology, 2019, p. -

Flotillin-1 (Flot1) is an evolutionary conserved, ubiquitously expressed lipid raft– associated scaffolding protein. Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II–mediated contractility. Flot1 also accumulates in the uropod of polarized T cells, suggesting an analogous role in T cell migration. In this study, we analyzed morphology and migration...

Université de Fribourg

Assessment of the potential for in-plume sulphur dioxide gas-ash interactions to influence the respiratory toxicity of volcanic ash

Tomašek, Ines ; Damby, David E. ; Horwell, Claire J. ; Ayris, Paul M. ; Delmelle, Pierre ; Ottley, Christopher J. ; Cubillas, Pablo ; Casas, Ana S. ; Bisig, Christoph ; Petri-Fink, Alke ; Dingwell, Donald B. ; Clift, Martin J. D. ; Drasler, Barbara ; Rothen-Rutishauser, Barbara

In: Environmental Research, 2019, vol. 179, p. 108798

Volcanic plumes are complex environments composed of gases and ash particles, where chemical and physical processes occur at different temperature and compositional regimes. Commonly, soluble sulphate- and chloride-bearing salts are formed on ash as gases interact with ash surfaces. Exposure to respirable volcanic ash following an eruption is potentially a significant health concern. The...

Université de Fribourg

Predicting abundances of invasive ragweed across Europe using a “top-down” approach

Skjøth, Carsten Ambelas ; Sun, Yan ; Karrer, Gerhard ; Sikoparija, Branko ; Smith, Matt ; Schaffner, Urs ; Müller-Schärer, Heinz

In: Science of The Total Environment, 2019, vol. 686, p. 212–222

Common ragweed (Ambrosia artemisiifolia L.) is a widely distributed and harmful invasive plant that is an important source of highly allergenic pollen grains and a prominent crop weed. As a result, ragweed causes huge costs to both human health and agriculture in affected areas. Efficient mitigation requires accurate mapping of ragweed densities that, until now, has not been achieved...

Université de Fribourg

A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*

Durmaz, Esra ; Rajpurohit, Subhash ; Betancourt, Nicolas ; Fabian, Daniel K. ; Kapun, Martin ; Schmidt, Paul ; Flatt, Thomas

In: Evolution, 2019, vol. 73, no. 9, p. 1774–1792

A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life‐history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single‐nucleotide polymorphism in insulin/insulin‐like growth factor...

Università della Svizzera italiana

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus

Sastry, Mallika ; Zhang, Baoshan ; Chen, Man ; Joyce, M. Gordon ; Kong, Wing-Pui ; Chuang, Gwo-Yu ; Ko, Kiyoon ; Kumar, Azad ; Silacci, Chiara ; Thom, Michelle ; Salazar, Andres M. ; Corti, Davide ; Lanzavecchia, Antonio ; Taylor, Geraldine ; Mascola, John R. ; Graham, Barney S. ; Kwong, Peter D.

In: Plos one, 2017, vol. 12, no. 10, p. e0186854

Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)—a highly prevalent childhood pathogen without a licensed vaccine—we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F) “DS-Cav1” immunogen, which induced high titer...

Università della Svizzera italiana

Molecular signatures of immunity and immunogenicity in infection and vaccination

Haks, Mariëlle C. ; Bottazzi, Barbara ; Cecchinato, Valentina ; De Gregorio, Corinne ; Del Giudice, Giuseppe ; Kaufmann, Stefan H. E. ; Lanzavecchia, Antonio ; Lewis, David J. M. ; Maertzdorf, Jeroen ; Mantovani, Alberto ; Sallusto, Federica ; Sironi, Marina ; Uguccioni, Mariagrazia ; Ottenhoff, Tom H. M.

In: Frontiers in immunology, 2017, vol. 8, p. 1563

Vaccinology aims to understand what factors drive vaccine-induced immunity and protection. For many vaccines, however, the mechanisms underlying immunity and protection remain incompletely characterized at best, and except for neutralizing antibodies induced by viral vaccines, few correlates of protection exist. Recent omics and systems biology big data platforms have yielded valuable...

Università della Svizzera italiana

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Yasinska, Inna M. ; Sakhnevych, Svetlana S. ; Pavlova, Ludmila ; Hansen Selnø, Anette Teo ; Teuscher Abeleira, Ana Maria ; Benlaouer, Ouafa ; Gonçalves Silva, Isabel ; Mosimann, Marianne ; Varani, Luca ; Bardelli, Marco ; Hussain, Rohanah ; Siligardi, Giuliano ; Cholewa, Dietmar ; Berger, Steffen M. ; Gibbs, Bernhard F. ; Ushkaryov, Yuri A. ; Fasler-Kan, Elizaveta ; Klenova, Elena ; Sumbayev, Vadim V.

In: Frontiers in immunology, 2019, vol. 10, p. 1594

Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand galectin-9 are involved in the immune escape of human acute myeloid leukemia (AML) cells. These cells use the neuronal receptor latrophilin 1...

Université de Fribourg

Targeted Capture of Hundreds of Nuclear Genes Unravels Phylogenetic Relationships of the Diverse Neotropical Palm Tribe Geonomateae

Loiseau, Oriane ; Olivares, Ingrid ; Paris, Margot ; Harpe, Marylaure de La ; Weigand, Anna ; Koubínová, Darina ; Rolland, Jonathan ; Bacon, Christine D. ; Balslev, Henrik ; Borchsenius, Finn ; Cano, Angela ; Couvreur, Thomas L. P. ; Delnatte, César ; Fardin, Frédérique ; Gayot, Marc ; Mejía, Fabian ; Mota-Machado, Talita ; Perret, Mathieu ; Roncal, Julissa ; Sanin, Maria José ; Stauffer, Fred ; Lexer, Christian ; Kessler, Michael ; Salamin, Nicolas

In: Frontiers in Plant Science, 2019, vol. 10, p. -

The tribe Geonomateae is a widely distributed group of 103 species of Neotropical palms which contains six ecologically important understory or subcanopy genera. Although it has been the focus of many studies, our understanding of the evolutionary history of this group, and in particular of the taxonomically complex genus Geonoma, is far from complete due to a lack of molecular data....

Université de Fribourg

A Language Index of Grammatical Gender Dimensions to Study the Impact of Grammatical Gender on the Way We Perceive Women and Men

Gygax, Pascal Mark ; Elmiger, Daniel ; Zufferey, Sandrine ; Garnham, Alan ; Sczesny, Sabine ; von Stockhausen, Lisa ; Braun, Friederike ; Oakhill, Jane

In: Frontiers in Psychology, 2019, vol. 10, no. 1604, p. 1-6

Psycholinguistic investigations of the way readers and speakers perceive gender have shown several biases associated with how gender is linguistically realized in language. Although such variations across languages offer interesting grounds for legitimate cross- linguistic comparisons, pertinent characteristics of grammatical systems – especially in terms of their gender asymmetries – have to...

Université de Fribourg

Split-critical and uniquely split-colorable graphs

Ekim, Tina ; Ries, Bernard ; de Werra, Dominique

In: Discrete Mathematics and Theoretical Computer Science, 2010, vol. 12, no. 5, p. 1-24

The split-coloring problem is a generalized vertex coloring problem where we partition the vertices into a minimum number of split graphs. In this paper, we study some notions which are extensively studied for the usual vertex coloring and the cocoloring problem from the point of view of split-coloring, such as criticality and the uniqueness of the minimum split-coloring. We discuss some...