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Università della Svizzera italiana

Advanced metaheuristics for the probabilistic orienteering problem

Chou, Xiaochen ; Gambardella, Luca Maria (Dir.) ; Montemanni, Roberto (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO020.

Stochastic Optimization Problems take uncertainty into account. For this reason they are in general more realistic than deterministic ones, meanwhile, more difficult to solve. The challenge is both on modelling and computation aspects: exact methods usually work only for small instances, besides, there are several problems with no closed-form expression or hard- to-compute objective functions....

Université de Fribourg

Self-avoiding walk on $\mathbb{Z}^{2}$ with Yang–Baxter weights: Universality of critical fugacity and 2-point function

Glazman, Alexander ; Manolescu, Ioan

In: Annales de l’Institut Henri Poincaré, Probabilités et Statistiques, 2020, vol. 56, no. 4, p. 2281–2300

We consider a self-avoiding walk model (SAW) on the faces of the square lattice Z2. This walk can traverse the same face twice, but crosses any edge at most once. The weight of a walk is a product of local weights: each square visited by the walk yields a weight that depends on the way the walk passes through it. The local weights are parametrised by angles θ∈[π3,2π3] and satisfy the...

Université de Fribourg

Identification of avoidance genes through neural pathway-specific forward optogenetics

Marques, Filipe ; Saro, Gabriella ; Lia, Andrei-Stefan ; Poole, Richard J. ; Falquet, Laurent ; Glauser, Dominique A.

In: PLOS Genetics, 2019, vol. 15, no. 12, p. e1008509

Understanding how the nervous system bridges sensation and behavior requires the elucidation of complex neural and molecular networks. Forward genetic approaches, such as screens conducted in C. elegans, have successfully identified genes required to process natural sensory stimuli. However, functional redundancy within the underlying neural circuits, which are often organized with multiple...

Université de Fribourg

NESSi: The Non-Equilibrium Systems Simulation package

Schüler, Michael ; Golež, Denis ; Murakami, Yuta ; Bittner, Nikolaj ; Herrmann, Andreas ; U.R.Strand, Hugo ; Werner, Philipp ; Eckstein, Martin

In: Computer Physics Communications, 2020, vol. 257, no. 2020, p. 107484

The nonequilibrium dynamics of correlated many-particle systems is of interest in connection with pump–probe experiments on molecular systems and solids, as well as theoretical investigations of transport properties and relaxation processes. Nonequilibrium Green’s functions are a powerful tool to study interaction effects in quantum many-particle systems out of equilibrium, and to extract...

Interkantonale Hochschule für Heilpädagogik Zürich HfH

Occupational career patterns over 30 years: predictors and outcomes

Schellenberg, Claudia: Interkantonale Hochschule für Heilpädagogik ; Krauss, Annette ; Hättich, Achim ; Häfeli, Kurt

In: Empirical Research in Vocational Education and Training, 2016, vol. 8, no. 15, p. 1-22

Background: Investigating individuals’ sequences of occupations and identifying suitable patterns is a complex task. Most research focuses on single time-points, single jobs and single transitions and only few longitudinal studies have investigated career paths over a long period of time. The aim of this study is to describe occupational career patterns (OCP) over a period of 30 years using...

Université de Fribourg

Holistic view on cell survival and dna damage: how model-based data analysis supports exploration of dynamics in biological systems

Weyland, Mathias S. ; Thumser-Henner, Pauline ; Nytko, Katarzyna J. ; Rohrer Bley, Carla ; Ulzega, Simone ; Petri-Fink, Alke ; Lattuada, Marco ; Füchslin, Rudolf M. ; Scheidegger, Stephan

In: Computational and Mathematical Methods in Medicine, 2020, vol. 2020, p. 1–11

In this work, a method is established to calibrate a model that describes the basic dynamics of DNA damage and repair. The model can be used to extend planning for radiotherapy and hyperthermia in order to include the biological effects. In contrast to “syntactic” models (e.g., describing molecular kinetics), the model used here describes radiobiological semantics, resulting in a more...

Università della Svizzera italiana

Voronoi-like diagrams : towards linear-time algorithms for tree-like abstract Voronoi diagrams

Junginger, Kolja ; Papadopoulou, Evanthia (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO013.

Computational Geometry is a subfield of Algorithm Design and Analysis with a focus on the design and analysis of algorithms related to discrete geometric objects. The Voronoi diagram is one of the most important structures in Computational Geometry providing proximity information, which is applicable to many different fields of science. For a given set of points in the plane – called sites...

Université de Fribourg

Unsupervised and Parameter-Free Clustering of Large Graphs for Knowledge Exploration and Recommendation

Lutov, Artem ; Cudré-Mauroux, Philippe (Dir.)

Thèse de doctorat : Université de Fribourg, 2020 ; no. 2192.

We live in an Information Age, facing a rapid increase in the amount of information that is exchanged. This permanently growing amount of data makes the ability to store, analyze, and act upon information a primary concern (in addition to the obvious privacy, legal and ethical issues that are related), raising the question: “How can one consume Big Data and transformit into actionable...

Université de Fribourg

The elasticity of voter turnout: Investing 85 cents per voter to increase voter turnout by 4 percent

Schelker, Mark ; Schneiter, Marco

In: Electoral Studies, 2017, vol. 49, p. 65-74

In the aftermath of elections or ballots, the legitimacy of the result is regularly debated if voter turnout was considered to be low. Hence, discussions about legal reforms to increase turnout are common in most democracies. We analyze the impact of a very small change in voting costs on voter turnout. Some municipalities in the Swiss Canton of Bern reduced voting costs by prepaying the postage...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...