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Université de Fribourg

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

Anaraki, Neda Iranpour ; Sadeghpour, Amin ; Iranshahi, Kamran ; Toncelli, Claudio ; Cendrowska, Urszula ; Stellacci, Francesco ; Dommann, Alex ; Wick, Peter ; Neels, Antonia

In: Nano Research, 2020, vol. 13, no. 10, p. 2847–2856

Nanoparticle (NP) colloidal stability plays a crucial role in biomedical application not only for human and environmental safety but also for NP efficiency and functionality. NP agglomeration is considered as a possible process in monodispersed NP colloidal solutions, which drastically affects colloidal stability. This process is triggered by changes in the physicochemical properties of the...

Université de Fribourg

Silica nanoparticles enhance disease resistance in Arabidopsis plants

El-Shetehy, Mohamed ; Moradi, Aboubakr ; Maceroni, Mattia ; Reinhardt, Didier ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Mauch, Felix ; Schwab, Fabienne

In: Nature Nanotechnology, 2020, p. 1–10

In plants, pathogen attack can induce an immune response known as systemic acquired resistance that protects against a broad spectrum of pathogens. In the search for safer agrochemicals, silica nanoparticles (SiO2 NPs; food additive E551) have recently been proposed as a new tool. However, initial results are controversial, and the molecular mechanisms of SiO2 NP-induced disease resistance...

Université de Fribourg

Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion

Estermann, Manuela ; Huang, Yen-Lin ; Septiadi, Dedy ; Ritz, Danilo ; Liang, Ching-Yeu ; Jacob, Francis ; Drasler, Barbara ; Petri-Fink, Alke ; Heinzelmann-Schwarz, Viola ; Rothen-Rutishauser, Barbara

In: PLOS ONE, 2020, vol. 15, no. 12, p. e0241500

The presence of ascites in the peritoneal cavity leads to morphological and functional changes of the peritoneal mesothelial cell layer. Cells loose cell-cell interactions, rearrange their cytoskeleton, activate the production of fibronectin, and change their cell surface morphology in a proinflammatory environment. Moreover, ovarian cancer cell adhesion has been shown to be facilitated by...

Université de Fribourg

Carbon‐assisted stable silver nanostructures

Abdollahi, S. Narjes ; Ochoa Martínez, Efraín ; Kilchoer, Cédric ; Kremer, Geoffroy ; Jaouen, Thomas ; Aebi, Philipp ; Hellmann, Tim ; Mayer, Thomas ; Gu, Yibei ; Wiesner, Ulrich B. ; Steiner, Ullrich ; Wilts, Bodo D. ; Gunkel, Ilja

In: Advanced Materials Interfaces, 2020, vol. 7, no. 23, p. 2001227

Nanostructured silver stands out among other plasmonic materials because its optical losses are the lowest of all metals. However, nanostructured silver rapidly degrades under ambient conditions, preventing its direct use in most plasmonic applications. Here, a facile and robust method for the preparation of highly stable nanostructured silver morphologies is introduced. 3D nanostructured...

Université de Fribourg

Shear stress-responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates

Rifaie‐Graham, Omar ; Galensowske, Nikolas F. B. ; Dean, Charlie ; Pollard, Jonas ; Balog, Sandor ; Gouveia, Micael G. ; Chami, Mohamed ; Vian, Antoine ; Amstad, Esther ; Lattuada, Marco ; Bruns, Nico

In: Angewandte Chemie International Edition, 2020, p. -

Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction compartments, is transferred to polymer-based nanoreactors. Amphiphilic block copolymers that carry nucleobases in their hydrophobic block...

Université de Fribourg

Protein complexes and neighborhoods driving autophagy

Siva Sankar, Devanarayanan ; Dengjel, Jörn

In: Autophagy, 2020, vol. 0, no. 0, p. 1–17

Autophagy summarizes evolutionarily conserved, intracellular degradation processes targeting cytoplasmic material for lysosomal degradation. These encompass constitutive processes as well as stress responses, which are often found dysregulated in diseases. Autophagy pathways help in the clearance of damaged organelles, protein aggregates and macromolecules, mediating their recycling and ...

Université de Fribourg

Increased uptake of silica nanoparticles in inflamed macrophages but not upon co-exposure to micron-sized particles

Susnik, Eva ; Taladriz-Blanco, Patricia ; Drasler, Barbara ; Balog, Sandor ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Cells, 2020, vol. 9, no. 9, p. 2099

Silica nanoparticles (NPs) are widely used in various industrial and biomedical applications. Little is known about the cellular uptake of co-exposed silica particles, as can be expected in our daily life. In addition, an inflamed microenvironment might affect a NP’s uptake and a cell’s physiological response. Herein, prestimulated mouse J774A.1 macrophages with bacterial...

Université de Fribourg

When plants and plastic interact

Schwab, Fabienne ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nature Nanotechnology, 2020, vol. 15, no. 9, p. 729–730

Overcoming the challenges of plastic detection in plants has made it possible to transfer many of the lessons learned from plant–metal nanoparticle interactions to plastic nanoparticles.

Université de Fribourg

An in vitro lung system to assess the proinflammatory hazard of carbon nanotube aerosols

Barosova, Hana ; Karakocak, Bedia Begum ; Septiadi, Dedy ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 15, p. 5335

In vitro three-dimensional (3D) lung cell models have been thoroughly investigated in recent years and provide a reliable tool to assess the hazard associated with nanomaterials (NMs) released into the air. In this study, a 3D lung co-culture model was optimized to assess the hazard potential of multiwalled carbon nanotubes (MWCNTs), which is known to provoke inflammation and fibrosis,...

Université de Fribourg

Rapid and sensitive quantification of cell-associated multi-walled carbon nanotubes

Steinmetz, Lukas ; Bourquin, Joel ; Barosova, Hana ; Haeni, Laetitia ; Caldwell, Jessica ; Milosevic, Ana ; Geers, Christoph ; Bonmarin, Mathias ; Taladriz-Blanco, Patricia ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: Nanoscale, 2020, vol. 12, no. 33, p. 17362–17372

Evaluating nanomaterial uptake and association by cells is relevant for in vitro studies related to safe-by-design approaches, nanomedicine or applications in photothermal therapy. However, standard analytical techniques are time-consuming, involve complex sample preparation or include labelling of the investigated sample system with e.g. fluorescent dyes. Here, we explore lock-in...