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Université de Fribourg

Life-history evolution and the genetics of fitness components in drosophila melanogaster

Flatt, Thomas

In: Genetics, 2020, vol. 214, no. 1, p. 3–48

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span—are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding of adaptation. Due to its simple and rapid life cycle, cosmopolitan...

Université de Fribourg

How flies turn food into progeny

Flatt, Thomas

In: eLife, 2019, vol. 8, p. e51289

Sex-optimal diets have different effects on gene expression in female and male flies.

Université de Fribourg

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Kvainickas, Arunas ; Nägele, Heike ; Qi, Wenjing ; Dokládal, Ladislav ; Jimenez-Orgaz, Ana ; Stehl, Luca ; Gangurde, Dipak ; Zhao, Qian ; Hu, Zehan ; Dengjel, Jörn ; Virgilio, Claudio De ; Baumeister, Ralf ; Steinberg, Florian

In: The Journal of Cell Biology, 2019, vol. 218, no. 9, p. 3019–3038

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer stimulate mTORC1 translocation to the lysosomal membrane, which leads to a loss of mTORC1...

Université de Fribourg

Wolbachia modifies thermal preference in Drosophila melanogaster

Truitt, Amy M. ; Kapun, Martin ; Kaur, Rupinder ; Miller, Wolfgang J.

In: Environmental Microbiology, 2019, vol. 21, no. 9, p. 3259–3268

Environmental variation can have profound and direct effects on fitness, fecundity, and host–symbiont interactions. Replication rates of microbes within arthropod hosts, for example, are correlated with incubation temperature but less is known about the influence of host–symbiont dynamics on environmental preference. Hence, we conducted thermal preference (Tp) assays and tested if...