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Université de Fribourg

Targeting GATA transcription factors – a novel strategy for anti-aging interventions?

Zimmermann, Andreas ; Kainz, Katharina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Schroeder, Sabrina ; Dengjel, Jörn ; Pietrocola, Federico ; Kepp, Oliver ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Sigrist, Stephan J. ; Madeo, Frank ; Kroemer, Guido ; Carmona-Gutierrez, Didac

In: Microbial Cell, 2019, vol. 6, no. 5, p. 212–216

GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged...