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Université de Fribourg

A Neighborhood for Complex Job Shop Scheduling Problems with Regular Objectives

Bürgy, Reinhard

In: Journal of Scheduling, 2017, vol. 20, p. 391-422

Due to the limited applicability in practice of the classical job shop scheduling problem, many researchers have addressed more complex versions of this problem by including additional process features, such as time lags, setup times, and buffer limitations, and have pursued objectives that are more practically relevant than the makespan, such as total flow time and total weighted tardiness....

Université de Fribourg

Protein complexes and neighborhoods driving autophagy

Siva Sankar, Devanarayanan ; Dengjel, Jörn

In: Autophagy, 2020, vol. 0, no. 0, p. 1–17

Autophagy summarizes evolutionarily conserved, intracellular degradation processes targeting cytoplasmic material for lysosomal degradation. These encompass constitutive processes as well as stress responses, which are often found dysregulated in diseases. Autophagy pathways help in the clearance of damaged organelles, protein aggregates and macromolecules, mediating their recycling and ...

Université de Fribourg

Rapid genomic and phenotypic change in response to climate warming in a widespread plant invader

Sun, Yan ; Bossdorf, Oliver ; Grados, Ramon D. ; Liao, Zhi, Yong ; Müller‐Schärer, Heinz

In: Global Change Biology, 2020//n/a/-

Predicting plant distributions under climate change is constrained by our limited understanding of potential rapid adaptive evolution. In an experimental evolution study with the invasive common ragweed (Ambrosia artemisiifolia L.) we subjected replicated populations of the same initial genetic composition to simulated climate warming. Pooled DNA sequencing of parental and offspring...