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Università della Svizzera italiana

Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7-/- mice

Perruzza, Lisa ; Strati, Francesco ; Gargari, Giorgio ; D’Erchia, Anna Maria ; Fosso, Bruno ; Pesole, Graziano ; Guglielmetti, Simone ; Grassi, Fabio

In: Scientific reports, 2019, vol. 9, p. 9315

The secretory immunoglobulin A (SIgA) in mammalian gut protects the organism from infections and contributes to host physiology by shaping microbiota composition. The mechanisms regulating the adaptive SIgA response towards gut microbes are poorly defined. Deletion of P2rx7, encoding for the ATP-gated ionotropic P2X7 receptor, leads to T follicular helper (Tfh) cells expansion in the Peyer’s...

Consortium of Swiss Academic Libraries

The SLC34 family of sodium-dependent phosphate transporters

Wagner, Carsten ; Hernando, Nati ; Forster, Ian ; Biber, Jürg

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 1, p. 139-153

Université de Fribourg

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

Flatt, Thomas ; Heyland, Andreas ; Rus, Florentina ; Porpiglia, Ermelinda ; Sherlock, Chris ; Yamamoto, Rochele ; Garbuzov, Alina ; Palli, Subba R. ; Tatar, Marc ; Silverman, Neal

In: The Journal of Experimental Biology, 2008, vol. 21, no. 1, p. 2712-2724

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-specific manner. Previous evidence suggests that JH and 20E might modulate innate immunity, but...

Université de Fribourg

Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects

Rodrigues, Marisa A. ; Flatt, Thomas

In: Current Opinion in Insect Science, 2016, vol. 16, p. 1–8

In most animals reproduction trades off with somatic maintenance and survival. Physiologically this trade-off is mediated by hormones with opposite effects on reproduction and maintenance. In many insects, this regulation is achieved by an endocrine network that integrates insulin-like/IGF-1 signaling (IIS), juvenile hormone (JH), and the yolk precursor vitellogenin (Vg) (or, more generally,...