In: European Journal of Pharmaceutics and Biopharmaceutics, 2019, vol. 139, p. 253–261
Resiquimod (R848), a member of the imidazoquinoline family, is a Toll-like receptor 7/8 agonist with high potency for cancer immunotherapy. However, tolerance induction and adverse effects limit its development as a drug. Encapsulation in a polymer matrix can circumvent these limitations, as shown in our formerly published approach where R848 was loaded into polylactic acid (PLA)-based...
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In: Journal of Biomolecular NMR, 2012, vol. 52, no. 2, p. 179-190
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In: Phosphorus, Sulfur, and Silicon and the Related Elements, 2017, p. -
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In: Tetrahedron, 2018, vol. 74, no. 1, p. 28–41
The influence of a N heteroatom on the ring conformations of six- and seven- membered aliphatic rings in six new C(O)NHP(O)-based phosphoric triamide structures (analysed by X-ray crystallography) is investigated. Additionally the influence of steric and crystal packing effects is also studied by the analysis of Hirshfeld surfaces. The results are compared to analogous structures with three-...
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In: Chemical Papers, 2017, vol. 71, no. 10, p. 1809–1823
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In: Journal of Steroids & Hormonal Science, 2016, vol. 2016, p. -
Pathogen-related yeast protein 1 (Pry1) is a Saccharomyces cerevisiae member of the CAP/SCP/TAPS superfamily. Although, CAP proteins have been proposed to be implicated in a number of physiological processes, such as pathogen virulence, sperm maturation and fertilization, host-pathogen interactions and defense mechanisms, the molecular mode of action of these proteins is poorly understood....
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In: Acta Crystallographica C, 2016, vol. 72, p. 230-233
Mercury(II) exhibits a strong preference for linear coordination which has been attributed to relativistic effects splitting the 6p orbitals and promoting sp hybridization. If the two ligands attached to the mercury(II) ion are weak donors, the metal ion can act as a good Lewis acid and expand its coordination number. Moreover, mercury has a special affinity for softer bases,...
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In: Journal of the Iranian Chemical Society, 2015, vol. 12, no. 12, p. 2093–2103
Hirshfeld surfaces and two-dimensional fingerprint plots are used to visualize and analyse intermolecular interactions in two new organotin(IV)-phosphoryl complexes: [Sn(CH₃)₂[OP(O)(OCH₃)₂]₂]n (I) and {[(4-CH₃)C₆H₄NH][C₅H₉(4-CH₃)N]₂P(O)}Sn(CH₃)₂Cl₂ (II). In (I), the asymmetric unit is composed of the Sn(CH₃)₂[OP(O)(OCH₃)₂]₂ segment bonded to the...
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In: The Plant Journal, 2014, vol. 77, no. 1, p. 108–118
Plant growth is achieved predominantly by cellular elongation, which is thought to be controlled on several levels by apoplastic auxin. Auxin export into the apoplast is achieved by plasma membrane efflux catalysts of the PIN-FORMED (PIN) and ATP-binding cassette protein subfamily B/phosphor-glycoprotein (ABCB/PGP) classes; the latter were shown to depend on interaction with the FKBP42, TWISTED...
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In: Weed Technology, 2013, vol. 27, no. 2, p. 405–411
This study determined the potential of the tortoise beetle (Coleoptera: Chrysomelidae) to control Canada thistle (Asteraceae) in Iran. Genetic analysis of the tortoise beetle, based on mitochondrial DNA, confirmed the presence of the species in Iran. A field experiment using five insect densities (0 to 20 larvae plant−1) showed a positive correlation between the number of larvae transferred and...
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