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Università della Svizzera italiana

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

Romagnani, Andrea ; Vettore, Valentina ; Rezzonico-Jost, Tanja ; Hampe, Sarah ; Rottoli, Elsa ; Nadolni, Wiebke ; Perotti, Michela ; Meier, Melanie A. ; Hermanns, Constanze ; Geiger, Sheila ; Wennemuth, Gunther ; Recordati, Camilla ; Matsushita, Masayuki ; Muehlich, Susanne ; Proietti, Michele ; Chubanov, Vladimir ; Gudermann, Thomas ; Grassi, Fabio ; Zierler, Susanna

In: Nature communications, 2017, vol. 8, p. 1917

The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 R/R) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of ...

Université de Fribourg

DNA‐mediated self‐assembly of plasmonic antennas with a single quantum dot in the hot spot

Nicoli, Francesca ; Zhang, Tao ; Hübner, Kristina ; Jin, Boyuan ; Selbach, Florian ; Acuna, Guillermo P. ; Argyropoulos, Christos ; Liedl, Tim ; Pilo-Pais, and Mauricio

In: Small, 2019, vol. 15, no. 26, p. 1804418

DNA self‐assembly is a powerful tool to arrange optically active components with high accuracy in a large parallel manner. A facile approach to assemble plasmonic antennas consisting of two metallic nanoparticles (40 nm) with a single colloidal quantum dot positioned at the hot spot is presented here. The design approach is based on DNA complementarity, stoichiometry, and steric hindrance...

Université de Fribourg

Distance dependence of single-molecule energy transfer to graphene measured with DNA origami nanopositioners

Kaminska, I. ; Bohlen, J. ; Rocchetti, S. ; Selbach, F. ; Acuna, Guillermo P. ; Tinnefeld, P.

In: Nano Letters, 2019, vol. 19, no. 7, p. 4257–4262

Despite the thorough investigation of graphene since 2004, altering its surface chemistry and reproducible functionalization remain challenging. This hinders fabrication of more complex hybrid materials with controlled architectures, and as a consequence the development of sensitive and reliable sensors and biological assays. In this contribution, we introduce DNA origami structures as...

Consortium of Swiss Academic Libraries

Wall crossing for symplectic vortices and quantum cohomology

Cieliebak, Kai ; Salamon, Dietmar

In: Mathematische Annalen, 2006, vol. 335, no. 1, p. 133-192