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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

Jürgens, Tanja ; Jafari, Mehrnoosh ; Kreutzfeldt, Mario ; Bahn, Erik ; Brück, Wolfgang ; Kerschensteiner, Martin ; Merkler, Doron

In: Brain, 2016, vol. 139, no. 1, p. 39-46

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Volpi, Vera G. ; Ferri, Cinzia ; Fregno, Ilaria ; Del Carro, Ubaldo ; Bianchi, Francesca ; Scapin, Cristina ; Pettinato, Emanuela ; Solda, Tatiana ; Feltri, M. Laura ; Molinari, Maurizio ; Wrabetz, Lawrence ; D’Antonio, Maurizio

In: PLOS genetics, 2019, vol. 15, no. 4, p. e1008069

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the...

Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes’ length and branching

Lichvarova, Lucia ; Blum, Walter ; Schwaller, Beat ; Szabolcsi, Viktoria

In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603

Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...

Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination

Rodriguez, Enrique ; Wegner, Christiane ; Kreutzfeldt, Mario ; Neid, Katharina ; Thal, Dietmar ; Jürgens, Tanja ; Brück, Wolfgang ; Stadelmann, Christine ; Merkler, Doron

In: Acta Neuropathologica, 2014, vol. 128, no. 2, p. 231-246

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, Susanne ; Jumpertz, Thorsten ; Hüttenrauch, Melanie ; Ogorek, Isabella ; Gerber, Hermeto ; Storck, Steffen E. ; Zampar, Silvia ; Dimitrov, Mitko ; Lehmann, Sandra ; Lepka, Klaudia ; Berndt, Carsten ; Wiltfang, Jens ; Becker-Pauly, Christoph ; Beher, Dirk ; Pietrzik, Claus U. ; Fraering, Patrick C. ; Wirths, Oliver

In: Acta Neuropathologica, 2019, vol. 137, no. 2, p. 239–257

Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, studies of autopsy brain samples from AD patients have demonstrated that a...

To become a pain specialist one has to understand the nervous system, yet the specialists of the nervous system still have a long way to go before understanding pain

Marchettini, P. ; Solaro, C. ; Sommer, C. ; Cruccu, G.

In: Neurological Sciences, 2007, vol. 28, no. 4, p. 161-162

Lame Ducks or Fierce Creatures? - The Role of Oligodendrocytes in Multiple Sclerosis

Zeis, T. ; Schaeren-Wiemers, N.

In: Journal of Molecular Neuroscience, 2008, vol. 35, no. 1, p. 91-100

Training-related modulations of the autonomic nervous system in endurance athletes: is female gender cardioprotective?

Fürholz, Monika ; Radtke, Thomas ; Roten, Laurent ; Tanner, Hildegard ; Wilhelm, Ilca ; Schmid, Jean-Paul ; Saner, Hugo ; Wilhelm, Matthias

In: European Journal of Applied Physiology, 2013, vol. 113, no. 3, p. 631-640

Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings

Lövblad, Karl-Olof ; Ramelli, Gianpaolo ; Remonda, Luca ; Nirkko, Arto ; Ozdoba, Christoph ; Schroth, Gerhard

In: Pediatric Radiology, 1997, vol. 27, no. 2, p. 155-158

The effect of insulin on cardiac autonomic balance predicts weight reduction after gastric bypass

Bobbioni-Harsch, E. ; Sztajzel, J. ; Barthassat, V. ; Lehmann, T. ; Sievert, K. ; Chassot, G. ; Huber, O. ; Morel, P. ; Golay, A. ; Assimacopoulos-Jeannet, F.

In: Diabetologia, 2005, vol. 48, no. 7, p. 1258-1263