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Université de Fribourg

Effects of statins to reduce all-cause mortality in heart failure patients: findings from the epical2 cohort study

Al‑Gobari, Muaamar ; Agrinier, Nelly ; Soudant, Marc ; Burnand, Bernard ; Thilly, Nathalie

In: American Journal of Cardiovascular Drugs, 2019, vol. 19, no. 5, p. 497–508

Introduction: The addition of statins to standard care in heart failure (HF) patients remains controversial in clinical practice. Large-scale clinical trials failed to show mortality benefits, but uncertainty persists in real-world settings.Objective: We evaluated whether the prescription of statins at hospital discharge is associated with a reduction in all-cause mortality at up to 1 year of...

Université de Fribourg

TASmania: A bacterial Toxin-Antitoxin Systems database

Akarsu, Hatice ; Bordes, Patricia ; Mansour, Moise ; Bigot, Donna-Joe ; Genevaux, Pierre ; Falquet, Laurent

In: PLOS Computational Biology, 2019, vol. 15, no. 4, p. e1006946

Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence. They are found in nearly all phyla and classified into 6 different types based on the mode of inactivation of the toxin, with the type II TAS being the best characterized so far. We have herein developed a new in silico discovery...

Università della Svizzera italiana

Exposing concurrency failures : a comprehensive survey of the state of the art and a novel approach to reproduce field failures

Bianchi, Francesco Adalberto ; Pezzè, Mauro (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO015.

With the rapid advance of multi-core and distributed architectures, concurrent systems are becoming more and more popular. Concurrent systems are extremely hard to develop and validate, as their overall behavior depends on the non-deterministic interleaving of the execution flows that comprise the system. Wrong and unexpected interleavings may lead to concurrency faults that are extremely...

Haute école de gestion de Genève

Analysis of Instagram product placement influence on consumers for the beauty industry

Schmidt, Elia ; De Schepper, Jan (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2018 ; TDIBM 44.

At a time where technology and digital is omnipresent, Influencer marketing became the new tool for digital marketing. Lately, social media, in particular Instagram, became as much as social network as a marketing platform for business. In this thesis, the author analyses the influence of Instagram product placement on consumers for the beauty industry. The purpose of this research is to...

Université de Neuchâtel

Phylogenetics as a tool for evolutionary studies : evolution of leafcutter bees and chemical ecology of bee-flower relationships

Trunz, Vincent ; Praz, Christophe (Dir.) ; Rasmann, Sergio (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

Bees are present in almost all terrestrial ecosystems and are of vital importance for the pollination of wild flowers and cultivated crops. Despite being well investigated compared to many other insects, numerous open questions remain on their taxonomy, phylogeny and ecology. The present thesis aims at filling some of the gaps in knowledge concerning the evolutionary and natural history of bees....

Université de Fribourg

Xenacoelomorpha survey reveals that all 11 animal homeobox gene classes were present in the first bilaterians

Brauchle, Michael ; Bilican, Adem ; Eyer, Claudia ; Bailly, Xavier ; Martínez, Pedro ; Ladurner, Peter ; Bruggmann, Rémy ; Sprecher, Simon G.

In: Genome Biology and Evolution, 2018, vol. 10, no. 9, p. 2205–2217

Homeodomain transcription factors are involved in many developmental processes across animals and have been linked to body plan evolution. Detailed classifications of these proteins identified 11 distinct classes of homeodomain proteins in animal genomes, each harboring specific sequence composition and protein domains. Although humans contain the full set of classes, Drosophila melanogaster...

Université de Fribourg

A model based two-stage classifier for airborne particles analyzed with Computer Controlled Scanning Electron Microscopy

Meier, Mario Federico ; Mildenberger, Thoralf ; Locher, René ; Rausch, Juanita ; Zünd, Thomas ; Neururer, Christoph ; Ruckstuhl, Andreas ; Grobéty, Bernard

In: Journal of Aerosol Science, 2018, vol. 123, p. 1–16

Computer controlled scanning electron microscopy (CCSEM) is a widely-used method for single airborne particle analysis. It produces extensive chemical and morphological data sets, whose processing and interpretation can be very time consuming. We propose an automated two-stage particle classification procedure based on elemental compositions of individual particles. A rule-based classifier is...