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Université de Fribourg

Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects

Garten, Matthias ; Prévost, Coline ; Cadart, Clotilde ; Gautier, Romain ; Bousset, Luc ; Melki, Ronald ; Bassereau, Patricia ; Vanni, Stefano

In: Physical Chemistry Chemical Physics, 2015, vol. 17, no. 24, p. 15589–15597

Alpha-synuclein (AS) is a synaptic protein that is directly involved in Parkinson's disease due to its tendency to form protein aggregates. Since AS aggregation can be dependent on the interactions between the protein and the cell plasma membrane, elucidating the membrane binding properties of AS is of crucial importance to establish the molecular basis of AS aggregation into toxic fibrils....

Université de Fribourg

Emerging climate signals in the Lena River catchment: a non-parametric statistical approach

Pohl, Eric ; Grenier, Christophe ; Vrac, Mathieu ; Kageyama, Masa

In: Hydrology and Earth System Sciences, 2020, vol. 24, no. 5, p. 2817–2839

Climate change has far-reaching implications in permafrost-underlain landscapes with respect to hydrology, ecosystems, and the population's traditional livelihoods. In the Lena River catchment, eastern Siberia, changing climatic conditions and the associated impacts are already observed or expected. However, as climate change progresses the question remains as to how far we are along this...

Haute Ecole de Gestion & Tourisme

SAP ERP – SAP S/4HANA Unterschiede in den Bereichen Reports, Queries und Workflows

Tadic, Marko ; Maier, Werner (Dir.)

Mémoire de bachelor : Haute Ecole de Gestion & Tourisme, 2018.

In dieser Bachelorarbeit wurden die Unterschiede von SAP ERP und SAP S/4HANA in den Bereichen Reports, Queries und Workflows verglichen. Ausserdem wurde das neue Datenmo-dell von SAP S/4HANA analysiert. Des Weiteren wurden andere Lösungsvorschläge, wie zum Beispiel Cloud oder Mobile Angebote erforscht. Abschliessend wurden Key Performance In-dicators, für die Anwendung von SAP S/4HANA,...

Università della Svizzera italiana

A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation

De Muyt, Arnaud ; Pyatnitskaya, Alexandra ; Andréani, Jessica ; Ranjha, Lepakshi ; Laureau, Raphaëlle ; Fernandez-Vega, Ambra ; Holoch, Daniel ; Girard, Elodie ; Govin, Jérome ; Margueron, Raphaël ; Couté, Yohann ; Cejka, Petr ; Guérois, Raphaël ; Borde, Valérie

In: Genes and development, 2018, vol. 32, no. 3-4, p. 283-296

Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS...

Consortium of Swiss Academic Libraries

Theory of Decay of Superfluid Turbulence intheLow-Temperature Limit

Kozik, E. ; Svistunov, B.

In: Journal of Low Temperature Physics, 2009, vol. 156, no. 3-6, p. 215-267

Consortium of Swiss Academic Libraries

On Certain Kähler Quotients of Quaternionic Kähler Manifolds

Cortés, V. ; Louis, J. ; Smyth, P. ; Triendl, H.

In: Communications in Mathematical Physics, 2013, vol. 317, no. 3, p. 787-816