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Università della Svizzera italiana

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity

Bertelli, Roberta ; Di Donato, Armando ; Cioni, Michela ; Grassi, Fabio ; Ikehata, Masami ; Bonanni, Alice ; Rastaldi, Maria Pia ; Ghiggeri, Gian Marco

In: Plos one, 2014, vol. 9, no. 10, p. e111285

Immunosuppressive regulatory T cells (Tregs) have been hypothesized to exert a protective role in animal models of spontaneous (Buffalo/Mna) and/or drug induced (Adriamycin) nephrotic syndrome. In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs. LPS (12 mg/Kg) was given as single shot in C57BL/6,...

Consortium of Swiss Academic Libraries

Immunological aspects of atherosclerosis

Garrido-Urbani, S. ; Meguenani, M. ; Montecucco, F. ; Imhof, B.

In: Seminars in Immunopathology, 2014, vol. 36, no. 1, p. 73-91

Université de Fribourg

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, Susanne ; Jumpertz, Thorsten ; Hüttenrauch, Melanie ; Ogorek, Isabella ; Gerber, Hermeto ; Storck, Steffen E. ; Zampar, Silvia ; Dimitrov, Mitko ; Lehmann, Sandra ; Lepka, Klaudia ; Berndt, Carsten ; Wiltfang, Jens ; Becker-Pauly, Christoph ; Beher, Dirk ; Pietrzik, Claus U. ; Fraering, Patrick C. ; Wirths, Oliver

In: Acta Neuropathologica, 2019, vol. 137, no. 2, p. 239–257

Brain accumulation and aggregation of amyloid-β (Aβ) peptides is a critical step in the pathogenesis of Alzheimer’s disease (AD). Full-length Aβ peptides (mainly Aβ1–40 and Aβ1–42) are produced through sequential proteolytic cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. However, studies of autopsy brain samples from AD patients have demonstrated that a...

Consortium of Swiss Academic Libraries

Leukocyte recruitment in atherosclerosis: Potential targets for therapeutic approaches?

Braunersreuther, V. ; Mach, F.

In: Cellular and Molecular Life Sciences CMLS, 2006, vol. 63, no. 18, p. 2079-2088

Consortium of Swiss Academic Libraries

Atherosclerosis is an inflammatory disease

Montecucco, Fabrizio ; Mach, François

In: Seminars in Immunopathology, 2009, vol. 31, no. 1, p. 1-3

Consortium of Swiss Academic Libraries

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3

Pfaffen, Stefanie ; Frey, Katharina ; Stutz, Irène ; Roesli, Christoph ; Neri, Dario

In: European Journal of Nuclear Medicine and Molecular Imaging, 2010, vol. 37, no. 8, p. 1559-1565

Consortium of Swiss Academic Libraries

Anti-retinal autoantibodies in experimental ocular and systemic toxoplasmosis

Garweg, Justus ; de Kozak, Yvonne ; Goldenberg, Brigitte ; Boehnke, Matthias

In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2010, vol. 248, no. 4, p. 573-584