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Cranial neuropathies in granulomatosis with polyangiitis (Wegener's): a case-based review

Söderström, Ana ; Revaz, Sylvie ; Dudler, Jean

In: Clinical Rheumatology, 2015, vol. 34, no. 3, p. 591-596

Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy

Grimm, Alexander ; Décard, Bernhard ; Athanasopoulou, Ioanna ; Schweikert, Kathi ; Sinnreich, Michael ; Axer, Hubertus

In: Journal of Neurology, 2015, vol. 262, no. 4, p. 870-880

HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship

Bode, Heiko ; Bourquin, Florence ; Suriyanarayanan, Saranya ; Wei, Yu ; Alecu, Irina ; Othman, Alaa ; Von Eckardstein, Arnold ; Hornemann, Thorsten

In: Human Molecular Genetics, 2016, vol. 25, no. 5, p. 853-865

The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Clair, Carole ; Cohen, Marya ; Eichler, Florian ; Selby, Kevin ; Rigotti, Nancy

In: Journal of General Internal Medicine, 2015, vol. 30, no. 8, p. 1193-1203

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Kvainickas, Arunas ; Nägele, Heike ; Qi, Wenjing ; Dokládal, Ladislav ; Jimenez-Orgaz, Ana ; Stehl, Luca ; Gangurde, Dipak ; Zhao, Qian ; Hu, Zehan ; Dengjel, Jörn ; Virgilio, Claudio De ; Baumeister, Ralf ; Steinberg, Florian

In: The Journal of Cell Biology, 2019, vol. 218, no. 9, p. 3019–3038

Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer stimulate mTORC1 translocation to the lysosomal membrane, which leads to a loss of mTORC1...

The atypical receptor CCRL2 (C-C Chemokine Receptor-Like 2) does not act as a decoy receptor in endothelial cells

Mazzotti, Chiara ; Gagliostro, Vincenzo ; Bosisio, Daniela ; Del Prete, Annalisa ; Tiberio, Laura ; Thelen, Marcus ; Sozzani, Silvano

In: Frontiers in immunology, 2017, vol. 8, p. 1233

C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family. ACKRs bind chemokines but do not activate G protein-dependent signaling or cell functions. ACKRs were shown to regulate immune functions in vivo by their ability to scavenge chemokines from the local environment. This study was ...

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Volpi, Vera G. ; Ferri, Cinzia ; Fregno, Ilaria ; Del Carro, Ubaldo ; Bianchi, Francesca ; Scapin, Cristina ; Pettinato, Emanuela ; Solda, Tatiana ; Feltri, M. Laura ; Molinari, Maurizio ; Wrabetz, Lawrence ; D’Antonio, Maurizio

In: PLOS genetics, 2019, vol. 15, no. 4, p. e1008069

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the...

Injured axons instruct schwann cells to build constricting actin spheres to accelerate axonal disintegration

Vaquié, Adrien ; Sauvain, Alizée ; Duman, Mert ; Nocera, Gianluigi ; Egger, Boris ; Meyenhofer, Felix ; Falquet, Laurent ; Bartesaghi, Luca ; Chrast, Roman ; Lamy, Christophe Maurice ; Bang, Seokyoung ; Lee, Seung-Ryeol ; Jeon, Noo Li ; Ruff, Sophie ; Jacob, Claire

In: Cell Reports, 2019, vol. 27, no. 11, p. 3152-3166.e7

After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that are subsequently cleared by Schwann cells and later by macrophages. Axonal debris clearing is an early step of the repair process that facilitates regeneration. We show here that Schwann cells promote distal cut axon disintegration for timely clearing. By combining cell-based and in vivo...

Roles of innervation in developing and regenerating orofacial tissues

Pagella, Pierfrancesco ; Jiménez-Rojo, Lucia ; Mitsiadis, Thimios

In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 12, p. 2241-2251

Phosphoinositides and Charcot-Marie-Tooth disease: New keys to old questions

Suter, U.

In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 24, p. 3261-3265