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Università della Svizzera italiana

Shp-2 is dispensable for establishing T cell exhaustion and for PD-1 signaling in vivo

Rota, Giorgia ; Niogret, Charlène ; Dang, Anh Thu ; Ramon Barros, Cristina ; Fonta, Nicolas Pierre ; Alfei, Francesca ; Morgado, Leonor ; Zehn, Dietmar ; Birchmeier, Walter ; Vivier, Eric ; Guarda, Greta

In: Cell reports, 2018, vol. 23, no. 1, p. 39-49

In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether Shp-2 is responsible in vivo for such dysfunctional responses remains elusive. To address this, we generated T cell- specific Shp-2-deficient mice. These...

Université de Fribourg

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Lan, Qiang ; Peyvandi, Sanam ; Duffey, Nathalie ; Huang, Yu-Ting ; Barras, David ; Held, Werner ; Richard, François ; Delorenzi, Mauro ; Sotiriou, Christos ; Desmedt, Christine ; Lorusso, Girieca ; Rüegg, Curzio

In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...

Università della Svizzera italiana

Consensus protocols exploiting network programmability

Dang, Huynh Tu ; Soulé, Robert (Dir.) ; Pedone, Fernando (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO003.

Services rely on replication mechanisms to be available at all time. The service demanding high availability is replicated on a set of machines called replicas. To maintain the consistency of replicas, a consensus protocol such as Paxos or Raft is used to synchronize the replicas' state. As a result, failures of a minority of replicas will not affect the service as other non-faulty replicas...

Consortium of Swiss Academic Libraries

Alveolar and Lactogenic Differentiation

Brisken, Cathrin ; Rajaram, Renuga

In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 3-4, p. 239-248

Consortium of Swiss Academic Libraries

Notch and cancer: a double-edged sword

Koch, U. ; Radtke, F.

In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 21, p. 2746-2762

Consortium of Swiss Academic Libraries

Notch and cancer: a double-edged sword

Koch, U. ; Radtke, F.

In: Cellular and Molecular Life Sciences, 2008, vol. 65, no. 6, p. 1005-1005

Consortium of Swiss Academic Libraries

Role of Lymphatic Vessels in Tumor Immunity: Passive Conduits or Active Participants?

Lund, Amanda ; Swartz, Melody

In: Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 341-352