Università della Svizzera italiana

Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Università della Svizzera italiana

Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ

Paroni, Gabriela ; Zanetti, Adriana ; Barzago, Maria Monica ; Kurosaki, Mami ; Guarrera, Luca ; Fratelli, Maddalena ; Troiani, Martina ; Ubezio, Paolo ; Bolis, Marco ; Vallerga, Arianna ; Biancardi, Federica ; Terao, Mineko ; Garattini, Enrico

In: Cancers, 2020, vol. 12, no. 10, p. 23 p

Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...

Consortium of Swiss Academic Libraries

The prevalence of rheumatic diseases in the elderly in developed countries and its evolution over time

Mariller, Marjorie ; Santos-Eggimann, Brigitte

In: Sozial- und Präventivmedizin/Social and Preventive Medicine, 2005, vol. 50, no. 1, p. 45-51

Consortium of Swiss Academic Libraries

Prevention of recurrent hip fracture

Staeger, P. ; Burnand, B. ; Santos-Eggimann, B. ; Klay, M. ; Siffert, C. ; Livio, J. ; Burckhardt, P. ; Paccaud, F.

In: Aging Clinical and Experimental Research, 2000, vol. 12, no. 1, p. 13-21

Consortium of Swiss Academic Libraries

Key elements in the statistical analysis of surveys

Berchtold, André

In: International Journal of Public Health, 2007, vol. 52, no. 2, p. 117-119

Consortium of Swiss Academic Libraries

Breast cancer screening among women with intellectual disability

Bouchardy Magnin, Christine

In: Sozial- und Präventivmedizin/Social and Preventive Medicine, 2004, vol. 49, no. 6, p. 361-362