In: Haematologica, 2019, vol. 105, no. 12, p. 2774–2784
While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE located downstream of the EPO gene, but this 3' HRE is dispensable for renal EPO gene...
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In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...
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In: Scientific Reports, 2019, vol. 9, no. 1, p. 1–14
Sex development, a complex and indispensable process in all vertebrates, has still not been completely elucidated, although new genes involved in sex development are constantly being discovered and characterized. Chromobox Homolog 2 (CBX2) is one of these new additions and has been identified through a 46,XY girl with double heterozygous variants on CBX2.1, causing Differences of Sex...
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In: Biological Chemistry, 2015, vol. 396, no. 4, p. 311-327
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In: Frontiers in Cellular Neuroscience, 2019, vol. 13, p. -
Chromatin immunoprecipitation (ChIP) is an assay developed in order to define the dynamic nature of transcription processes. This method has been widely employed to identify methylated and acetylated DNA sequences in a variety of organs both in animals and humans. Nevertheless, this technique is significantly less employed to study transcriptional targets of specific nuclear signaling factors...
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Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO001.
Long noncoding RNAs (lncRNAs) have gained increasing interest in molecular studies, their active participation in important biological functions has emerged and their direct involvement in genomic reprogramming during development and diseases, including cancer, has been demonstrated. Several studies have shown their active contribution in transcriptional control and they are emerging as...
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In: Plant Molecular Biology, 1998, vol. 38, no. 5, p. 785-795
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In: Cellular and Molecular Life Sciences, 2010, vol. 67, no. 20, p. 3407-3423
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In: Journal of Mammary Gland Biology and Neoplasia, 2001, vol. 6, no. 1, p. 141-150
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In: Biometals, 2006, vol. 19, no. 1, p. 61-70
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