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Université de Fribourg

Inhibition of p38mapk reduces adipose tissue inflammation in aging mediated by arginase-II

Huang, Ji ; Liu, Chang ; Ming, Xiu-Fen ; Yang, Zhihong

In: Pharmacology, 2020, vol. 105, no. 9–10, p. 491–504

Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity. However, the role of Arg-II in aging adipose tissue inflammation is not clear....

Université de Fribourg

Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II)

Zuhra, Karim ; Panagaki, Theodora ; B.Randi, Elisa ; Augsburger, Fiona ; Blondel, Marc ; Friocourt, Gaelle ; Herault, Yann ; Szabo, Csaba

In: Biochemical Pharmacology, 2020, vol. 182, p. 114267

Background: Hydrogen sulfide (H2S) is an endogenous mammalian gasotransmitter. Cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3- mercaptopyruvate sulfurtransferase (3-MST) are the principal enzymes responsible for its biogenesis. A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of...

Université de Fribourg

Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control

Ribordy Lambert, Farfalla ; Wicht, Corentin A. ; Mouthon, Michael ; Spierer, Lucas

In: NeuroImage, 2020, vol. 215, p. 116811

While the deleterious effects of acute ethyl alcohol intoxication on executive control are well-established, the underlying spatiotemporal brain mechanisms remain largely unresolved. In addition, since the effects of alcohol are noticeable to participants, isolating the effects of the substance from those related to expectations represents a major challenge. We addressed these issues using a...

Université de Fribourg

Effects of continuous theta burst stimulation over the left DLPFC on mother tongue and second language production in late bilinguals: a behavioral and ERP study

Jost, Lea B. ; Pestalozzi, Maria I. ; Cazzoli, Dario ; Mouthon, Michael ; Müri, René M. ; Annoni, Jean‑Marie

In: Brain Topography, 2020, vol. 33, no. 4, p. 504–518

Clinical, neuroimaging, and non-invasive brain stimulation studies have associated the dorsolateral prefrontal cortex (DLPFC) with the multilingual language control system. Here, we investigated if this role is increased during the processing of the non- dominant language due to the higher cognitive/attentional demands. We used an inhibitory repetitive transcranial magnetic stimulation (rTMS)...

Université de Fribourg

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Yu, Yi ; Ladeiras, Diogo ; Xiong, Yuyan ; Boligan, Kayluz Frias ; Liang, Xiujie ; Gunten, Stephan ; Hunger, Robert E. ; Ming, Xiu‐Fen ; Yang, Zhihong

In: Journal of Cellular Physiology, 2020, p. jcp.29814

Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...

Université de Fribourg

Linking comparative genomics of nine potato-associated pseudomonas isolates with their differing biocontrol potential against late blight

Vrieze, Mout De ; Varadarajan, Adithi R. ; Schneeberger, Kerstin ; Bailly, Aurélien ; Rohr, Rudolf P. ; Ahrens, Christian H. ; Weisskopf, Laure

In: Frontiers in Microbiology, 2020, vol. 11, p. 857

For plants, the advantages of associating with beneficial bacteria include plant growth promotion, reduction of abiotic and biotic stresses and enhanced protection against various pests and diseases. Beneficial bacteria rightly equipped for successful plant colonization and showing antagonistic activity toward plant pathogens seem to be actively recruited by plants. To gain more insights into...

Université de Fribourg

Training‐, muscle‐ and task‐specific up‐ and downregulation of cortical inhibitory processes

Taube, Wolfgang ; Gollhofer, Albert ; Lauber, Benedikt

In: European Journal of Neuroscience, 2020, vol. 51, no. 6, p. 1428–1440

Motor cortical contribution was shown to be important for balance control and for ballistic types of movements. However, little is known about the role of cortical inhibitory mechanisms and even less about long(er)‐term adaptations of these inhibitory processes. Therefore, the aim of the present study was to investigate the role of intracortical inhibition before and after four weeks of ...

Université de Fribourg

Countermovement jump training is more effective than drop jump training in enhancing jump height in non-professional female volleyball players

Ruffieux, Jan ; Wälchli, Michael ; Kim, Kyung-Min ; Taube, Wolfgang

In: Frontiers in Physiology, 2020, vol. 11, p. -

The aim of the present study was to compare the effects of countermovement jump (CMJ) and drop jump (DJ) training on the volleyball-specific jumping ability of non-professional female volleyball players. For that purpose, 26 female volleyball players (15–32 years) were assigned to either a CMJ (20.4 ± 3.1 years, 171.0 ± 3.0 cm) or a DJ training group (22.0 ± 4.4 years, 168.2 ± 5.0 cm), ...

Université de Fribourg

Effects of theta burst stimulation over the dorsolateral prefrontal cortex on language switching – A behavioral and ERP study

Pestalozzi, Maria I. ; Annoni, Jean-Marie ; Müri, René M. ; Jost, Lea B.

In: Brain and Language, 2020, vol. 205, p. 104775

This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either excitatory or inhibitory TBS over the left DLPFC before conducting picture naming tasks in pure language blocks and a language switching...

Université de Fribourg

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...