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Université de Fribourg

No evidence that frontal optical flow affects perceived locomotor speed and locomotor biomechanics when running on a treadmill

Caramenti, Martina ; Lafortuna, Claudio L. ; Mugellini, Elena ; Khaled, Omar Abou ; Bresciani, Jean-Pierre ; Dubois, Amandine

In: Applied Sciences, 2019, vol. 9, no. 21, p. 4589

We investigated how the presentation and the manipulation of an optical flow while running on a treadmill affect perceived locomotor speed (Experiment 1) and gait parameters (Experiment 2). In Experiment 1, 12 healthy participants were instructed to run at an imposed speed and to focus on their sensorimotor sensations to be able to reproduce this running speed later. After a pause, they had...

Université de Fribourg

A biologically-inspired model to predict perceived visual speed as a function of the stimulated portion of the visual field

Solari, Fabio ; Caramenti, Martina ; Chessa, Manuela ; Pretto, Paolo ; Bülthoff, Heinrich H. ; Bresciani, Jean-Pierre

In: Frontiers in Neural Circuits, 2019, vol. 13, p. -

Spatial orientation relies on a representation of the position and orientation of the body relative to the surrounding environment. When navigating in the environment, this representation must be constantly updated taking into account the direction, speed, and amplitude of body motion. Visual information plays an important role in this updating process, notably via optical flow. Here, we...

Université de Fribourg

Interpretation of clinical data and hypothesis testing with the aid of self-collected data from physiology laboratory courses: a teaching approach for medical students

Grasser, Erik Konrad ; Montani, Jean-Pierre

In: Advances in Physiology Education, 2019, vol. 43, no. 4, p. 557–560

More than 50 million scientific articles were published between 1665 and 2009 (4), with millions more expected every year (6). This incomprehensible number accounts for scientific articles alone and does not encompass various “pseudo-scientific” information and articles that are spread, without any peer review process, by social media and blogs, thereby generating a potential source of...

Université de Fribourg

Assessment of the potential for in-plume sulphur dioxide gas-ash interactions to influence the respiratory toxicity of volcanic ash

Tomašek, Ines ; Damby, David E. ; Horwell, Claire J. ; Ayris, Paul M. ; Delmelle, Pierre ; Ottley, Christopher J. ; Cubillas, Pablo ; Casas, Ana S. ; Bisig, Christoph ; Petri-Fink, Alke ; Dingwell, Donald B. ; Clift, Martin J. D. ; Drasler, Barbara ; Rothen-Rutishauser, Barbara

In: Environmental Research, 2019, vol. 179, p. 108798

Volcanic plumes are complex environments composed of gases and ash particles, where chemical and physical processes occur at different temperature and compositional regimes. Commonly, soluble sulphate- and chloride-bearing salts are formed on ash as gases interact with ash surfaces. Exposure to respirable volcanic ash following an eruption is potentially a significant health concern. The...

Université de Fribourg

Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

Mitterer, Valentin ; Shayan, Ramtin ; Ferreira-Cerca, Sébastien ; Murat, Guillaume ; Enne, Tanja ; Rinaldi, Dana ; Weigl, Sarah ; Omanic, Hajrija ; Gleizes, Pierre-Emmanuel ; Kressler, Dieter ; Plisson-Chastang, Celia ; Pertschy, Brigitte

In: Nature Communications, 2019, vol. 10, no. 1, p. 2754

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre- ribosomes are coordinated is poorly understood. Using functional analyses and cryo- EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our...

Université de Fribourg

4,4’Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects

Zimmermann, Andreas ; Kainz, Katharina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Schroeder, Sabrina ; Dengjel, Jörn ; Pietrocola, Federico ; Kepp, Oliver ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Sigrist, Stephan J. ; Madeo, Frank ; Carmona-Gutierrez, Didac ; Kroemer, Guido

In: Autophagy, 2019, vol. 15, no. 9, p. 1662–1664

The age-induced deterioration of the organism results in detrimental and ultimately lethal pathologies. The process of aging itself involves a plethora of different mechanisms that should be subverted concurrently to delay and/or prevent age- related maladies. We have identified a natural compound, 4,4ʹ-dimethoxychalcone (DMC), which promotes longevity in yeast, worms and flies, and protects...