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Université de Fribourg

Eradication of a multidrug-resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom made, lytic bacteriophage preparation

Corbellino, Mario ; Kieffer, Nicolas ; Kutateladze, Mzia ; Balarjishvili, Nana ; Leshkasheli, Lika ; Askilashvili, Lia ; Tsertsvadze, George ; Rimoldi, Sara Giordana ; Nizharadze, Deia ; Hoyle, Naomi ; Nadareishvili, Lia ; Antinori, Spinello ; Pagani, Cristina ; Scorza, Daniele Giuseppe ; Romanò, Ai Ling Loredana ; Ardizzone, Sandro ; Danelli, Piergiorgio ; Gismondo, Maria Rita ; Galli, Massimo ; Nordmann, Patrice ; Poirel, Laurent

In: Clinical Infectious Diseases, 2020, vol. 70, no. 9, p. 1998–2001

In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.

Université de Fribourg

Colloidal transformations in ms2 virus particles: driven by ph, influenced by natural organic matter

Watts, Samuel ; Julian, Timothy R. ; Maniura-Weber, Katharina ; Graule, Thomas ; Salentinig, Stefan

In: ACS Nano, 2020, vol. 14, no. 2, p. 1879–1887

Enteric viruses, such as enterovirus, norovirus, and rotavirus, are among the leading causes of disease outbreaks due to contaminated drinking and recreational water. Viruses are difficult to remove from water through filtration based on physical size exclusion—for example by gravity-driven filters—due to their nanoscale size. To understand virus removal in drinking water treatment ...

Université de Fribourg

TASmania: A bacterial Toxin-Antitoxin Systems database

Akarsu, Hatice ; Bordes, Patricia ; Mansour, Moise ; Bigot, Donna-Joe ; Genevaux, Pierre ; Falquet, Laurent

In: PLOS Computational Biology, 2019, vol. 15, no. 4, p. e1006946

Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence. They are found in nearly all phyla and classified into 6 different types based on the mode of inactivation of the toxin, with the type II TAS being the best characterized so far. We have herein developed a new in silico discovery...

Université de Neuchâtel

Hydrogeological characterization of karst aquifers in Switzerland using a pragmatic approach

Malard, Arnauld ; Jeannin, Pierre-Yves (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Recent studies reveal that karst aquifers represent a significant part of the Swiss groundwater reserve (120 km3) and resource (8.4 km3/year), although they only extend over 20% of the territory. On the one hand, high infiltration rates and large permeabilities of karstified rocks make karst aquifers highly interesting for water management. On the other hand, karst...

Université de Neuchâtel

Hydrogeological and topographical controls on catchment dynamics and their implications for low flows

Carlier, Claire ; Brunner, Philip (Dir.) ; Hunkeler, Daniel (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Periods with scarce precipitation will likely occur more frequently and last longer under changing climatic conditions, even in relatively humid regions like Switzerland. To assess the sensitivity of water resources to dry spells and to identify regions that might experience water scarcity issues, a thorough understanding of the mechanisms governing catchment dynamics in the absence of rain is...

Université de Neuchâtel

Advances in characterizing surface water-groundwater interactions : combining unconventional data with complex, fully-integrated models

Schilling, Oliver S. ; Brunner, Philip (Dir.) ; Hunkeler, Daniel (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

The characterization and simulation of the interactions between surface water and groundwater require observations of hydrological state variables and flow processes. While the latest generation of physically-based flow models allows the integrated simulation of all relevant hydrological processes, the current modelling practice is not adequate to provide reliable predictions. Numerous studies...

Université de Neuchâtel

On the use of multiple-point statistics to improve groundwater flow modeling in karst aquifers : A case study from the Hydrogeological Experimental Site of Poitiers, France

Le Coz, M ; Bodin, J ; Renard, Philippe

In: Journal of Hydrology, 2017, vol. 545, p. 109-119

Limestone aquifers often exhibit complex groundwater flow behaviors resulting from depositional heterogeneities and post-lithification fracturing and karstification. In this study, multiple-point statistics (MPS) was applied to reproduce karst features and to improve groundwater flow modeling. For this purpose, MPS realizations were used in a numerical flow model to simulate the responses to...

Université de Fribourg

Physically based hydrogeological and slope stability modeling of the Turaida castle mound

Kukemilks, Karlis ; Wagner, Jean-Frank ; Saks, Tomas ; Brunner, Philip

In: Landslides, 2018, vol. 15, no. 11, p. 2267–2278

This study explores the potential of integrating state-of-the-art physically based hydrogeological modeling into slope stability simulations to identify the hydrogeological triggers of landslides. Hydrogeological models considering detailed morphological, lithological, and climatic factors were elaborated. Groundwater modeling reveals locations with elevated pore water pressures in the...