In: Clinical Infectious Diseases, 2020, vol. 70, no. 9, p. 1998–2001
In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.
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In: ACS Nano, 2020, vol. 14, no. 2, p. 1879–1887
Enteric viruses, such as enterovirus, norovirus, and rotavirus, are among the leading causes of disease outbreaks due to contaminated drinking and recreational water. Viruses are difficult to remove from water through filtration based on physical size exclusion—for example by gravity-driven filters—due to their nanoscale size. To understand virus removal in drinking water treatment ...
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In: PLOS Computational Biology, 2019, vol. 15, no. 4, p. e1006946
Bacterial Toxin-Antitoxin systems (TAS) are involved in key biological functions including plasmid maintenance, defense against phages, persistence and virulence. They are found in nearly all phyla and classified into 6 different types based on the mode of inactivation of the toxin, with the type II TAS being the best characterized so far. We have herein developed a new in silico discovery...
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Thèse de doctorat : Université de Neuchâtel, 2018.
Recent studies reveal that karst aquifers represent a significant part of the Swiss groundwater reserve (120 km3) and resource (8.4 km3/year), although they only extend over 20% of the territory. On the one hand, high infiltration rates and large permeabilities of karstified rocks make karst aquifers highly interesting for water management. On the other hand, karst...
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Thèse de doctorat : Université de Neuchâtel, 2018.
Periods with scarce precipitation will likely occur more frequently and last longer under changing climatic conditions, even in relatively humid regions like Switzerland. To assess the sensitivity of water resources to dry spells and to identify regions that might experience water scarcity issues, a thorough understanding of the mechanisms governing catchment dynamics in the absence of rain is...
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Thèse de doctorat : Université de Neuchâtel, 2017.
The characterization and simulation of the interactions between surface water and groundwater require observations of hydrological state variables and flow processes. While the latest generation of physically-based flow models allows the integrated simulation of all relevant hydrological processes, the current modelling practice is not adequate to provide reliable predictions. Numerous studies...
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In: Journal of Hydrology, 2017, vol. 545, p. 109-119
Limestone aquifers often exhibit complex groundwater flow behaviors resulting from depositional heterogeneities and post-lithification fracturing and karstification. In this study, multiple-point statistics (MPS) was applied to reproduce karst features and to improve groundwater flow modeling. For this purpose, MPS realizations were used in a numerical flow model to simulate the responses to...
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In: Landslides, 2018, vol. 15, no. 11, p. 2267–2278
This study explores the potential of integrating state-of-the-art physically based hydrogeological modeling into slope stability simulations to identify the hydrogeological triggers of landslides. Hydrogeological models considering detailed morphological, lithological, and climatic factors were elaborated. Groundwater modeling reveals locations with elevated pore water pressures in the...
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In: Applied Microbiology and Biotechnology, 2012, vol. 93, no. 2, p. 633-643
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In: Hydrogeology Journal, 2008, vol. 16, no. 7, p. 1311-1317
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