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Université de Fribourg

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Petrini, Francesco M. ; Mazzoni, Alberto ; Rigosa, Jacopo ; Giambattistelli, Federica ; Granata, Giuseppe ; Barra, Beatrice ; Pampaloni, Alessandra ; Guglielmelli, Eugenio ; Zollo, Loredana ; Capogrosso, Marco ; Micera, Silvestro ; Raspopovic, Stanisa

In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44

The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...

Université de Fribourg

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, Robert ; Mellows, Ben ; Sheard, Jonathan ; Antonioli, Manuela ; Kretz, Oliver ; Chambers, David ; Zeuner, Marie-Theres ; Tomkins, James E. ; Denecke, Bernd ; Musante, Luca ; Joch, Barbara ; Debacq-Chainiaux, Florence ; Holthofer, Harry ; Ray, Steve ; Huber, Tobias B. ; Dengjel, Joern ; De Coppi, Paolo ; Widera, Darius ; Patel, Ketan

In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116

The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...

Interkantonale Hochschule für Heilpädagogik Zürich HfH

Persistent hippocampal neural firing and hippocampal-cortical coupling predict verbal working memory load

Boran, Ece ; Fedele, Tommaso ; Klaver, Peter ; Hilfiker, Peter ; Stieglitz, Lennart ; Grunwald, Thomas ; Sarnthein, Johannes

In: Science Advances, 2019, vol. 5, no. 3, p. 1-14

The maintenance of items in working memory relies on persistent neural activity in a widespread network of brain areas. To investigate the influence of load on working memory, we asked human subjects to maintain sets of letters in memory while we recorded single neurons and intracranial encephalography (EEG) in the medial temporal lobe and scalp EEG. Along the periods of a trial, hippocampal...

Università della Svizzera italiana

Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

Jacquelot, Nicolas ; Enot, David P. ; Flament, Caroline ; Vimond, Nadège ; Blattner, Carolin ; Pitt, Jonathan M. ; Yamazaki, Takahiro ; Roberti, María Paula ; Daillère, Romain ; Vétizou, Marie ; Poirier-Colame, Vichnou ; Semeraro, Michaëla ; Caignard, Anne ; Slingluff Jr., Craig L. ; Sallusto, Federica ; Rusakiewicz, Sylvie ; Weide, Benjamin ; Marabelle, Aurélien ; Kohrt, Holbrook ; Dalle, Stéphane ; Cavalcanti, Andréa ; Kroemer, Guido ; Di Giacomo, Anna Maria ; Maio, Michele ; Wong, Phillip ; Yuan, Jianda ; Wolchok, Jedd ; Umansky, Viktor ; Eggermont, Alexander ; Zitvogel, Laurence

In: The journal of clinical investigation, 2016, vol. 126, no. 3, p. 921-937

Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and CD8+ T lymphocytes in 57 patients with metastatic melanoma (MMel) with various sites of metastases to evaluate...

Università della Svizzera italiana

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Rigoni, Rosita ; Fontana, Elena ; Guglielmetti, Simone ; Fosso, Bruno ; D’Erchia, Anna Maria ; Maina, Virginia ; Taverniti, Valentina ; Carmina Castiello, Maria ; Mantero, Stefano ; Pacchiana, Giovanni ; Musio, Silvia ; Pedotti, Rosetta ; Selmi, Carlo ; Mora, J. Rodrigo ; Pesole, Graziano ; Vezzoni, Paolo ; Poliani, Pietro Luigi ; Grassi, Fabio ; Villa, Anna ; Cassani, Barbara

In: The journal of experimental medicine, 2016, vol. 213, no. 3, p. 355-375

Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated. Here, we show that Rag2R229Q knock-in mice developed an inflammatory bowel disease affecting...

Università della Svizzera italiana

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

Venereau, Emilie ; Casalgrandi, Maura ; Schiraldi, Milena ; Antoine, Daniel J. ; Cattaneo, Angela ; De Marchis, Francesco ; Liu, Jaron ; Antonelli, Antonella ; Preti, Alessandro ; Raeli, Lorenzo ; Samadi Shams, Sara ; Yang, Huan ; Varani, Luca ; Andersson, Ulf ; Tracey, Kevin J. ; Bachi, Angela ; Uguccioni, Mariagrazia ; Bianchi, Marco E.

In: The journal of experimental medicine, 2012, vol. 209, no. 9, p. 1519-1528

Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine and further cysteine oxidation to...

Università della Svizzera italiana

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

Schiraldi, Milena ; Raucci, Angela ; Martínez Muñoz, Laura ; Livoti, Elsa ; Celona, Barbara ; Venereau, Emilie ; Apuzzo, Tiziana ; De Marchis, Francesco ; Pedotti, Mattia ; Bachi, Angela ; Thelen, Marcus ; Varani, Luca ; Mellado, Mario ; Proudfoot, Amanda ; Bianchi, Marco Emilio ; Uguccioni, Mariagrazia

In: The journal of experimental medicine, 2012, vol. 209, no. 3, p. 551-563

After tissue damage, inflammatory cells infiltrate the tissue and release proinflammatory cytokines. HMGB1 (high mobility group box 1), a nuclear protein released by necrotic and severely stressed cells, promotes cytokine release via its interaction with the TLR4 (Toll-like receptor 4) receptor and cell migration via an unknown mechanism. We show that HMGB1- induced recruitment of inflammatory...

Università della Svizzera italiana

miR-146a and NF-κB1 regulate mast cell survival and T lymphocyte differentiation

Rusca, Nicole ; Dehò, Lorenzo ; Montagner, Sara ; Zielinski, Christina E. ; Sica, Antonio ; Sallusto, Federica ; Monticelli, Silvia

In: Molecular and cellular biology, 2012, vol. 32, no. 21, p. 4432-4444

The transcription factor NF-κB regulates the expression of a broad number of genes central to immune and inflammatory responses. We identified a new molecular network that comprises specifically the NF-κB family member NF-κB1 (p50) and miR-146a, and we show that in mast cells it contributes to the regulation of cell homeostasis and survival, while in T lymphocytes it modulates T cell...

Université de Fribourg

Permafrost is warming at a global scale

Biskaborn, Boris K. ; Smith, Sharon L. ; Noetzli, Jeannette ; Matthes, Heidrun ; Vieira, Gonçalo ; Streletskiy, Dmitry A. ; Schoeneich, Philippe ; Romanovsky, Vladimir E. ; Lewkowicz, Antoni G. ; Abramov, Andrey ; Allard, Michel ; Boike, Julia ; Cable, William L. ; Christiansen, Hanne H. ; Delaloye, Reynald ; Diekmann, Bernhard ; Drozdov, Dmitry ; Etzelmüller, Bernd ; Grosse, Guido ; Guglielmin, Mauro ; Ingeman-Nielsen, Thomas ; Isaksen, Ketil ; Ishikawa, Mamoru ; Johansson, Margareta ; Johannsson, Halldor ; Joo, Anseok ; Kaverin, Dmitry ; Kholodov, Alexander ; Konstantinov, Pavel ; Kröger, Tim ; Lambiel, Christophe ; Lanckman, Jean-Pierre ; Luo, Dongliang ; Malkova, Galina ; Meiklejohn, Ian ; Moskalenko, Natalia ; Oliva, Marc ; Phillips, Marcia ; Ramos, Miguel ; Sannel, A. Britta K. ; Sergeev, Dmitrii ; Seybold, Cathy ; Skryabin, Pavel ; Vasiliev, Alexander ; Wu, Qingbai ; Yoshikawa, Kenji ; Zheleznyak, Mikhail ; Lantuit, Hugues

In: Nature Communications, 2019, vol. 10, no. 1, p. 264

Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across...

Université de Fribourg

The evolutionary genetics of canalization

Flatt, Thomas

In: The Quarterly Review of Biology, 2005, vol. 80, no. 3, p. 287-316

Evolutionary genetics has recently made enormous progress in understanding how genetic variation maps into phenotypic variation. However, why some traits are phenotypically invariant despite apparent genetic and environmental changes has remained a major puzzle. In the 1940s, Conrad Hal Waddington coined the concept and term “canalization” to describe the robustness of phenotypes to...