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Università della Svizzera italiana

Marine anticancer agents : an overview with a particular focus on their chemical classes

Barreca, Marilia ; Spanò, Virginia ; Montalbano, Alessandra ; Cueto, Mercedes ; Díaz Marrero, Ana R. ; Deniz, Irem ; Erdoğan, Ayşegül ; Lukić Bilela, Lada ; Moulin, Corentin ; Taffin-de-Givenchy, Elisabeth ; Spriano, Filippo ; Perale, Giuseppe ; Mehiri, Mohamed ; Rotter, Ana ; Thomas, Olivier P. ; Barraja, Paola ; Gaudêncio, Susana P. ; Bertoni, Francesco

In: Marine drugs, 2020, vol. 18, no. 12, p. 28

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from...

Université de Fribourg

The principle of equality in diverse states : reconciling autonomy with equal rights and opportunities

Belser, Eva Maria ; Bächler, Thea ; Egli, Sandra ; Zünd, Lawrence

Leiden : Brill, 2021

(Studies in territorial and cultural diversity governance ; 13)

ISBN: 9789004394612

This book examines different approaches by which states characterised by federal or decentralized arrangements reconcile equality and autonomy. In case studies from four continents, leading experts analyse the challenges of ensuring institutional, social and economic equality whilst respecting the competences of regions and the rights of groups.

Université de Fribourg

The record of Deinotheriidae from the Miocene of the Swiss Jura Mountains (Jura Canton, Switzerland)

Gagliardi, Fanny ; Maridet, Olivier ; Becker, Damien

In: bioRxiv, 2021, p. 244061

The Miocene sands of the Swiss Jura Mountains, long exploited in quarries for the construction industry, have yielded abundant fossil remains of large mammals. Among Deinotheriidae (Proboscidea), two species, Prodeinotherium bavaricum and Deinotherium giganteum, had previously been identified in the Delémont valley, but never described. A third species, Deinotherium levius, from the locality of...

Haute école de gestion de Genève

The implication of the new labor clauses in the USMCA on labor market and trade between the United States, Mexico and Canada

Stäuble, Mathieu ; Matile, Laurent (Dir.)

Mémoire de bachelor : Haute école de gestion de Genève, 2020 ; TDIBM 93.

The North American continent has implemented different free trade agreements throughout the years. From the Canadian-United States Free Trade Agreement (CUSFTA) reached in 1989, between Canada and the United States and quickly replaced by the North American Free Trade Agreement (NAFTA) in 1994 with the addition of Mexico to the agreement. After 26 years of existence and divergent opinions...

Université de Fribourg

Poly(ADP-ribose) polymerase inhibition in acute lung injury. A reemerging concept

Szabo, Csaba ; Martins, Vanessa ; Liaudet, Lucas

In: American Journal of Respiratory Cell and Molecular Biology, 2020, vol. 63, no. 5, p. 571–590

PARP1, the major isoform of a family of ADP-ribosylating enzymes, has been implicated in the regulation of various biological processes including DNA repair, gene transcription, and cell death. The concept that PARP1 becomes activated in acute lung injury (ALI) and that pharmacological inhibition or genetic deletion of this enzyme can provide therapeutic benefits emerged over 20 years ago....

Université de Fribourg

Disproportionate extinction of South American mammals drove the asymmetry of the Great American Biotic Interchange

Carrillo, Juan D. ; Faurby, Søren ; Silvestro, Daniele ; Zizka, Alexander ; Jaramillo, Carlos ; Bacon, Christine D. ; Antonelli, and Alexandre

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 42, p. 26281–26287

The biological interchange between North and South America associated with the formation of the Isthmus of Panama is key to defining current gradients of species diversity. A major gap in our understanding of the interchange is its asymmetry, where mammals of North American origin attained higher diversity in South America than vice versa. The prevailing view is that this asymmetry resulted...

Université de Fribourg

The Eomyidae in Asia: Biogeography, diversity and dispersals

Kimura, Yuri ; Casanovas-Vilar, Isaac ; Maridet, Olivier ; Kalthoff, Daniela C. ; Mörs, Thomas ; Tomida, Yukimitsu

In: Fossil Imprint, 2020, vol. 76, no. 1, p. 181-200

In Asia, the first find of an eomyid rodent was reported almost one century after the first studies of the family Eomyidae in North America and Europe. Since then, eomyid rodents have been increasingly found in Asia particularly over the past two decades. Here, we review the Asian record of this family at the genus level. Currently, 22 species within 14 genera were reported from Asia,...