In: Journal of Neurology, 2021, no. 268, p. 817–824
Background: Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients. Methods: Nested case–control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS...
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In: European journal of neurology, 2021, vol. 28, no. 9, p. 9
Background and purpose: Fatigue is amongst the most frequent and disabling symptoms of multiple sclerosis and a close relation between fatigue and sleep quality has been hypothesized. In this study the contribution of sleep disturbances measured by clinical and polysomnographic parameters to fatigue in multiple sclerosis was investigated. Methods: This was a prospective instrumental study...
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In: European Journal of International Management (EJIM), 2018, vol. 12, no. 4, p. 472-500
This cross-country study investigates the antecedents and outcomes of corporate social and environmental responsibility (CSER) practices. Based on institutional theory and stakeholder theory we conducted an empirical study among 519 firms in Denmark, Germany, and the Netherlands. We found evidence supporting a significant positive relationship between stakeholder pressures, CSER practices,...
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In: Journal of Systematic Palaeontology, 2021, p. 1-21
Rodents of the extant family Gliridae, commonly called dormice, are common in European faunas since the early Eocene. Here we study for the first time specimens from St-Martin-de-Castillon C (France, early Oligocene) previously reported as Gliravus aff. majori and Pseudodryomys aff. fugax. We now refer them to Butseloglis tenuis and Microdyromys misonnei. Besides the French material, new...
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In: bioRxiv, 2021, p. 244061
The Miocene sands of the Swiss Jura Mountains, long exploited in quarries for the construction industry, have yielded abundant fossil remains of large mammals. Among Deinotheriidae (Proboscidea), two species, Prodeinotherium bavaricum and Deinotherium giganteum, had previously been identified in the Delémont valley, but never described. A third species, Deinotherium levius, from the locality of...
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In: Swiss Journal of Economics and Statistics, 2020, vol. 156, no. 10, p. 1-19
We assess the impact of the timing of lockdown measures implemented in Germany and Switzerland on cumulative COVID-19-related hospitalization and death rates. Our analysis exploits the fact that the epidemic was more advanced in some regions than in others when certain lockdown measures came into force, based on measuring health outcomes relative to the region-specific start of the epidemic...
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In: Fossil Imprint, 2020, vol. 76, no. 1, p. 174-180
The maxillary presented in this work has been excavated in the middle Miocene karst filling Petersbuch 136 (Germany, Bavaria) and shows the oldest evidence of dental anomaly in a sciurid. The aberrant morphology, probably hyperdontia or no replacement of roots of deciduous teeth, affects the area of the P3, a tooth that is generally not well documented in the Spermophilinus record.
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In: PeerJ, 2020, p. e8322
The Southern Caucasus, with its special geographic position and complex topography, is a well-known biodiversity hotspot. However, the formation of this hotspot remains largely unstudied. To reveal this, a thorough study of the fossil record of the region is necessary. In the present paper, we describe for the first time fossil monitor lizards (Varanus sp.) from two late Miocene localities from...
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In: International journal of molecular sciences, 2020, vol. 21, no. 3, p. 21 p
The activation of the PI3K/AKT/mTOR pathway is a main driver of cell growth, proliferation, survival, and chemoresistance of cancer cells, and, for this reason, represents an attractive target for developing targeted anti- cancer drugs. There are plenty of preclinical data sustaining the anti-tumor activity of dual PI3K/mTOR inhibitors as single agents and in combination in lymphomas. Clinical...
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In: Palaeobiodiversity and Palaeoenvironments, 2019, vol. 99, no. 3, p. 527–543
Simplomys, a dormouse with a simple dental morphology compared to other glirids, shows a continuous evolution in Spain during the end of the Ramblian and up to the middle Aragonian, the stratigraphic frame considered in this work. In contrast, the record of the genus in Central Europe is reduced to a few localities spanning from the early to the middle Miocene. We review the record from the...
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