In: Scientific Reports, 2020, vol. 10, p. 5505
The origin of turtles is one of the most long-lasting debates in evolutionary research. During their evolution, a series of modifications changed their relatively kinetic and anapsid skull into an elongated akinetic structure with a unique pulley system redirecting jaw adductor musculature. These modifications were thought to be strongly correlated to functional adaptations, especially to bite...
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In: Nature Neuroscience, 2018, vol. 21, no. 12, p. 1728–1741
Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and proprioceptive information in humans. Computational simulations and preclinical and clinical experiments reveal that EES blocks a significant amount of...
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In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -
The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal cord. Depending on the location of these neurons, loading of their synaptic vesicles with glutamate is mediated by either of three vesicular...
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In: Journal of Neurology, 2011, vol. 258, no. 8, p. 1406-1412
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In: Organisms Diversity & Evolution, 2013, vol. 13, no. 2, p. 225-254
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In: Neuroscience, 2018, vol. 373, p. 106–112
Research has indicated that at the onset of a finger movement, unwanted contractions of adjacent muscles are prevented by inhibiting the cortical areas representing these muscles. This so-called surround inhibition (SI) seems relevant for the performance of selective finger movements but may not be necessary for tasks involving functional coupling between different finger muscles. Therefore,...
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In: Scientific Reports, 2018, vol. 8, no. 1, p. 76
After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance...
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In: Journal of Vertebrate Paleontology, 2017, vol. 37, no. 4, p. e1333121
The bone tissue of femur, rib, and gastralia from three different individuals of the Middle Triassic pseudosuchian Batrachotomus kupferzellensis from southern Germany is studied. The femoral bone tissue comprises laminar fibrolamellar bone tissue throughout and is stratified by three annual growth cycles, indicating that the individual died early in its fourth year of life, at which time it...
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In: BMC Evolutionary Biology, 2016, vol. 16, p. 188
Archosauromorpha originated in the middle–late Permian, radiated during the Triassic, and gave rise to the crown group Archosauria, a highly successful clade of reptiles in terrestrial ecosystems over the last 250 million years. However, scientific attention has mainly focused on the diversification of archosaurs, while their stem lineage (i.e. non- archosaurian archosauromorphs) has often...
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In: Behavioural Brain Research, 2016, vol. 301, p. 33–42
Motor impairments in human gait following stroke or focal brain damage are well documented. Here, we investigated whether stroke and/or focal brain damage also affect the navigational component of spatially oriented locomotion. Ten healthy adult participants and ten adult brain-damaged patients had to walk towards distant targets from different starting positions (with vision or blindfolded). No...
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